Expression of GNB3 in cancer - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	GNB3
Gene description	Guanine nucleotide binding protein (G protein), beta polypeptide 3
Protein class	Plasma proteins Predicted intracellular proteins RAS pathway related proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (testis cancer)
HPA (cell line):	Cell line enhanced (NTERA-2, U-698)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Membranous and cytoplasmic expression at variable levels in several different cell types.

ANTIBODY IHC RELIABILITY
Data reliability description	Caution, targets protein from more than one gene. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA040736
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (testis cancer)

PROTEIN EXPRESSION

STAINING SUMMARY

HPA040736

GENE INFORMATION
Gene name	GNB3
Synonyms
Description	Guanine nucleotide binding protein (G protein), beta polypeptide 3 (HGNC Symbol)
Entrez gene summary	Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit which belongs to the WD repeat G protein beta family. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. A single-nucleotide polymorphism (C825T) in this gene is associated with essential hypertension and obesity. This polymorphism is also associated with the occurrence of the splice variant GNB3-s, which appears to have increased activity. GNB3-s is an example of alternative splicing caused by a nucleotide change outside of the splice donor and acceptor sites. Alternative splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Jul 2014]
Chromosome	12
Cytoband	p13.31
Chromosome location (bp)	6839954 - 6847393
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000111664 (version 83.38)
Entrez gene	2784
UniProt	P16520 (UniProt - Evidence at protein level)
neXtProt	NX_P16520
Antibodypedia	GNB3 antibodies

PROTEIN BROWSER

GNB3-002	GNB3-005	GNB3-007	GNB3-009	GNB3-011

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GNB3-002 ENSP00000229264 ENST00000229264	P16520 [Direct mapping] Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 F1T0G5 [Target identity:100%; Query identity:100%] Guanine nucleotide binding protein (G protein), beta polypeptide 3; Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 Show all	Predicted intracellular proteins Plasma proteins RAS pathway related proteins Protein evidence (Kim et al 2014) Show all	GO:0003924 [GTPase activity] GO:0004871 [signal transducer activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006112 [energy reserve metabolic process] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007268 [synaptic transmission] GO:0008217 [regulation of blood pressure] GO:0030425 [dendrite] GO:0030507 [spectrin binding] GO:0043005 [neuron projection] GO:0044281 [small molecule metabolic process] GO:0044297 [cell body] GO:0051020 [GTPase binding] GO:0070062 [extracellular exosome] GO:0071377 [cellular response to glucagon stimulus] Show all	340 aa 37.2 kDa	No	0
GNB3-005 ENSP00000414734 ENST00000435982	E9PCP0 [Direct mapping] Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 Show all	Predicted intracellular proteins RAS pathway related proteins Show all	GO:0005515 [protein binding] GO:0007165 [signal transduction] Show all	339 aa 37.1 kDa	No	0
GNB3-007 ENSP00000442002 ENST00000541257	F5H8J8 [Direct mapping] Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 Show all	Predicted intracellular proteins RAS pathway related proteins Show all	GO:0005515 [protein binding] GO:0007165 [signal transduction] Show all	232 aa 25.5 kDa	No	0
GNB3-009 ENSP00000445967 ENST00000537035	F5H0S8 [Direct mapping] Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 Show all	Predicted intracellular proteins RAS pathway related proteins Show all	GO:0005515 [protein binding] GO:0007165 [signal transduction] Show all	265 aa 29.3 kDa	No	0
GNB3-011 ENSP00000439753 ENST00000541978	F5H100 [Direct mapping] Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 Show all	Predicted intracellular proteins RAS pathway related proteins Show all	GO:0005515 [protein binding] GO:0007165 [signal transduction] Show all	232 aa 25.5 kDa	No	0