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GNB3

GENERAL INFORMATION

Gene name

 GNB3

Gene description

 Guanine nucleotide binding protein (G protein), beta polypeptide 3

Protein class

 Plasma proteins
Predicted intracellular proteins
RAS pathway related proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Tissue enhanced (cerebellum, pituitary gland)
FANTOM5:Group enriched (pituitary gland, retina)

Protein evidence

 Evidence at protein level

Protein expression

 Membranous and cytoplasmic expression at variable levels in several different cell types.

DATA RELIABILITY

Data reliability
description

 Caution, targets protein from more than one gene. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA040736
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cerebellum, pituitary gland)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (pituitary gland, retina)

GENE INFORMATION

Gene name

 GNB3

Synonyms

Description

 Guanine nucleotide binding protein (G protein), beta polypeptide 3 (HGNC Symbol)

Entrez gene summary

 Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit which belongs to the WD repeat G protein beta family. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. A single-nucleotide polymorphism (C825T) in this gene is associated with essential hypertension and obesity. This polymorphism is also associated with the occurrence of the splice variant GNB3-s, which appears to have increased activity. GNB3-s is an example of alternative splicing caused by a nucleotide change outside of the splice donor and acceptor sites. Alternative splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Jul 2014]

Chromosome

 12

Cytoband

 p13.31

Chromosome location (bp)

 6839954 - 6847393

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000111664 (version 83.38)

Entrez gene

 2784

UniProt

 P16520 (UniProt - Evidence at protein level)

neXtProt

 NX_P16520

Antibodypedia

 GNB3 antibodies

PROTEIN BROWSER
GNB3-002
GNB3-005
GNB3-007
GNB3-009
GNB3-011

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GNB3-002
ENSP00000229264
ENST00000229264
P16520 [Direct mapping]
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
F1T0G5 [Target identity:100%; Query identity:100%]
Guanine nucleotide binding protein (G protein), beta polypeptide 3; Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
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Predicted intracellular proteins
Plasma proteins
RAS pathway related proteins
Protein evidence (Kim et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0004871 [signal transducer activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0006112 [energy reserve metabolic process]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007268 [synaptic transmission]
GO:0008217 [regulation of blood pressure]
GO:0030425 [dendrite]
GO:0030507 [spectrin binding]
GO:0043005 [neuron projection]
GO:0044281 [small molecule metabolic process]
GO:0044297 [cell body]
GO:0051020 [GTPase binding]
GO:0070062 [extracellular exosome]
GO:0071377 [cellular response to glucagon stimulus]
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 340 aa
37.2 kDa 		No 0
GNB3-005
ENSP00000414734
ENST00000435982
E9PCP0 [Direct mapping]
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
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Predicted intracellular proteins
RAS pathway related proteins
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GO:0005515 [protein binding]
GO:0007165 [signal transduction]
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 339 aa
37.1 kDa 		No 0
GNB3-007
ENSP00000442002
ENST00000541257
F5H8J8 [Direct mapping]
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
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Predicted intracellular proteins
RAS pathway related proteins
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GO:0005515 [protein binding]
GO:0007165 [signal transduction]
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 232 aa
25.5 kDa 		No 0
GNB3-009
ENSP00000445967
ENST00000537035
F5H0S8 [Direct mapping]
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
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Predicted intracellular proteins
RAS pathway related proteins
Show all
GO:0005515 [protein binding]
GO:0007165 [signal transduction]
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 265 aa
29.3 kDa 		No 0
GNB3-011
ENSP00000439753
ENST00000541978
F5H100 [Direct mapping]
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
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Predicted intracellular proteins
RAS pathway related proteins
Show all
GO:0005515 [protein binding]
GO:0007165 [signal transduction]
Show all
 232 aa
25.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.