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TPI1

GENERAL INFORMATION

Gene name

 TPI1

Gene description

 Triosephosphate isomerase 1

Protein class

 Cancer-related genes
Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 8
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 General nuclear and cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Uncertain based on 2 antibodies.
HPA050924 , HPA053568
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 TPI1

Synonyms

Description

 Triosephosphate isomerase 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes an enzyme, consisting of two identical proteins, which catalyzes the isomerization of glyceraldehydes 3-phosphate (G3P) and dihydroxy-acetone phosphate (DHAP) in glycolysis and gluconeogenesis. Mutations in this gene are associated with triosephosphate isomerase deficiency. Pseudogenes have been identified on chromosomes 1, 4, 6 and 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]

Chromosome

 12

Cytoband

 p13.31

Chromosome location (bp)

 6867119 - 6870948

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000111669 (version 83.38)

Entrez gene

 7167

UniProt

 P60174 (UniProt - Evidence at protein level)

neXtProt

 NX_P60174

Antibodypedia

 TPI1 antibodies

PROTEIN BROWSER
TPI1-001
TPI1-002
TPI1-003
TPI1-004
TPI1-005
TPI1-008
TPI1-201
TPI1-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TPI1-001
ENSP00000229270
ENST00000229270
P60174 [Direct mapping]
Triosephosphate isomerase
Show all
Enzymes
   ENZYME proteins
   Isomerase
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004807 [triose-phosphate isomerase activity]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0005975 [carbohydrate metabolic process]
GO:0006006 [glucose metabolic process]
GO:0006094 [gluconeogenesis]
GO:0006096 [glycolytic process]
GO:0006098 [pentose-phosphate shunt]
GO:0007275 [multicellular organismal development]
GO:0008152 [metabolic process]
GO:0016853 [isomerase activity]
GO:0019563 [glycerol catabolic process]
GO:0019682 [glyceraldehyde-3-phosphate metabolic process]
GO:0031625 [ubiquitin protein ligase binding]
GO:0044281 [small molecule metabolic process]
GO:0046166 [glyceraldehyde-3-phosphate biosynthetic process]
GO:0061621 [canonical glycolysis]
GO:0070062 [extracellular exosome]
Show all
 286 aa
30.8 kDa 		No 0
TPI1-002
ENSP00000475620
ENST00000488464
P60174 [Direct mapping]
Triosephosphate isomerase
Show all
Enzymes
   ENZYME proteins
   Isomerase
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004807 [triose-phosphate isomerase activity]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0005975 [carbohydrate metabolic process]
GO:0006006 [glucose metabolic process]
GO:0006094 [gluconeogenesis]
GO:0006096 [glycolytic process]
GO:0006098 [pentose-phosphate shunt]
GO:0008152 [metabolic process]
GO:0019563 [glycerol catabolic process]
GO:0031625 [ubiquitin protein ligase binding]
GO:0044281 [small molecule metabolic process]
GO:0046166 [glyceraldehyde-3-phosphate biosynthetic process]
GO:0061621 [canonical glycolysis]
GO:0070062 [extracellular exosome]
Show all
 167 aa
18 kDa 		No 0
TPI1-003
ENSP00000475364
ENST00000493987
U3KPZ0 [Direct mapping]
Triosephosphate isomerase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004807 [triose-phosphate isomerase activity]
GO:0006094 [gluconeogenesis]
GO:0006096 [glycolytic process]
GO:0006098 [pentose-phosphate shunt]
GO:0008152 [metabolic process]
Show all
 113 aa
12.4 kDa 		No 0
TPI1-004
ENSP00000475184
ENST00000462761
U3KPS5 [Direct mapping]
Triosephosphate isomerase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004807 [triose-phosphate isomerase activity]
GO:0006094 [gluconeogenesis]
GO:0006096 [glycolytic process]
GO:0006098 [pentose-phosphate shunt]
GO:0008152 [metabolic process]
Show all
 39 aa
4.2 kDa 		No 0
TPI1-005
ENSP00000475829
ENST00000495834
U3KQF3 [Direct mapping]
Triosephosphate isomerase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004807 [triose-phosphate isomerase activity]
GO:0006094 [gluconeogenesis]
GO:0006096 [glycolytic process]
GO:0006098 [pentose-phosphate shunt]
GO:0008152 [metabolic process]
Show all
 98 aa
10.6 kDa 		No 0
TPI1-008
ENSP00000379933
ENST00000396705
P60174 [Direct mapping]
Triosephosphate isomerase
V9HWK1 [Target identity:100%; Query identity:100%]
Triosephosphate isomerase
Show all
Enzymes
   ENZYME proteins
   Isomerase
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004807 [triose-phosphate isomerase activity]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0005975 [carbohydrate metabolic process]
GO:0006006 [glucose metabolic process]
GO:0006094 [gluconeogenesis]
GO:0006096 [glycolytic process]
GO:0006098 [pentose-phosphate shunt]
GO:0008152 [metabolic process]
GO:0019563 [glycerol catabolic process]
GO:0031625 [ubiquitin protein ligase binding]
GO:0044281 [small molecule metabolic process]
GO:0046166 [glyceraldehyde-3-phosphate biosynthetic process]
GO:0061621 [canonical glycolysis]
GO:0070062 [extracellular exosome]
Show all
 249 aa
26.7 kDa 		No 0
TPI1-201
ENSP00000443599
ENST00000535434
P60174 [Direct mapping]
Triosephosphate isomerase
Show all
Enzymes
   ENZYME proteins
   Isomerase
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004807 [triose-phosphate isomerase activity]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0005975 [carbohydrate metabolic process]
GO:0006006 [glucose metabolic process]
GO:0006094 [gluconeogenesis]
GO:0006096 [glycolytic process]
GO:0006098 [pentose-phosphate shunt]
GO:0008152 [metabolic process]
GO:0019563 [glycerol catabolic process]
GO:0031625 [ubiquitin protein ligase binding]
GO:0044281 [small molecule metabolic process]
GO:0046166 [glyceraldehyde-3-phosphate biosynthetic process]
GO:0061621 [canonical glycolysis]
GO:0070062 [extracellular exosome]
Show all
 167 aa
18 kDa 		No 0
TPI1-202
ENSP00000484435
ENST00000613953
P60174 [Direct mapping]
Triosephosphate isomerase
Show all
Enzymes
   ENZYME proteins
   Isomerase
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004807 [triose-phosphate isomerase activity]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0005975 [carbohydrate metabolic process]
GO:0006006 [glucose metabolic process]
GO:0006094 [gluconeogenesis]
GO:0006096 [glycolytic process]
GO:0006098 [pentose-phosphate shunt]
GO:0008152 [metabolic process]
GO:0019563 [glycerol catabolic process]
GO:0031625 [ubiquitin protein ligase binding]
GO:0044281 [small molecule metabolic process]
GO:0046166 [glyceraldehyde-3-phosphate biosynthetic process]
GO:0061621 [canonical glycolysis]
GO:0070062 [extracellular exosome]
Show all
 286 aa
30.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.