Expression of SLCO1B3 in cancer - Summary

GENERAL INFORMATION
Gene name	SLCO1B3
Gene description	Solute carrier organic anion transporter family, member 1B3
Protein class	Disease related genes Potential drug targets Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (liver cancer)
HPA (cell line):	Cell line enhanced (A-431, A549, PC-3, U-2 OS)
HPA (normal tissue):	Tissue enriched (liver)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective membranous expression in liver along with extracellular positivity in liver.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA004943 , HPA050892
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (liver cancer)

PROTEIN EXPRESSION

STAINING SUMMARY

HPA004943	HPA050892

GENE INFORMATION
Gene name	SLCO1B3 (HGNC Symbol)
Synonyms	OATP1B3, OATP8, SLC21A8
Description	Solute carrier organic anion transporter family, member 1B3 (HGNC Symbol)
Entrez gene summary	This gene encodes a liver-specific member of the organic anion transporter family. The encoded protein is a transmembrane receptor that mediates the sodium-independent uptake of endogenous and xenobiotic compounds and plays a critical role in bile acid and bilirubin transport. Mutations in this gene are a cause of Rotor type hyperbilirubinemia. [provided by RefSeq, Feb 2012]
Chromosome	12
Cytoband	p12.2
Chromosome location (bp)	20810702 - 20916911
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000111700 (version 83.38)
Entrez gene	28234
UniProt	Q9NPD5 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NPD5
Antibodypedia	SLCO1B3 antibodies

PROTEIN BROWSER

SLCO1B3-001	SLCO1B3-003	SLCO1B3-005	SLCO1B3-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLCO1B3-001 ENSP00000370956 ENST00000381545	Q9NPD5 [Direct mapping] Solute carrier organic anion transporter family member 1B3 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Show all	GO:0005215 [transporter activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0008206 [bile acid metabolic process] GO:0008514 [organic anion transmembrane transporter activity] GO:0015125 [bile acid transmembrane transporter activity] GO:0015347 [sodium-independent organic anion transmembrane transporter activity] GO:0015711 [organic anion transport] GO:0015721 [bile acid and bile salt transport] GO:0016020 [membrane] GO:0016323 [basolateral plasma membrane] GO:0043252 [sodium-independent organic anion transport] GO:0044281 [small molecule metabolic process] GO:0055085 [transmembrane transport] GO:0098656 [anion transmembrane transport] Show all	702 aa 77.4 kDa	No	>9
SLCO1B3-003 ENSP00000442000 ENST00000540853	F5H8K0 [Direct mapping] Solute carrier organic anion transporter family member Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Show all	GO:0005215 [transporter activity] GO:0005886 [plasma membrane] GO:0006810 [transport] GO:0006811 [ion transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	291 aa 32.2 kDa	No	5
SLCO1B3-005 ENSP00000443225 ENST00000544370	H0YGG9 [Direct mapping] Solute carrier organic anion transporter family member Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0005215 [transporter activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006810 [transport] GO:0006811 [ion transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	479 aa 52.8 kDa	No	7
SLCO1B3-201 ENSP00000261196 ENST00000261196	Q9NPD5 [Direct mapping] Solute carrier organic anion transporter family member 1B3 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes Potential drug targets Show all	GO:0005215 [transporter activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0008206 [bile acid metabolic process] GO:0008514 [organic anion transmembrane transporter activity] GO:0015125 [bile acid transmembrane transporter activity] GO:0015347 [sodium-independent organic anion transmembrane transporter activity] GO:0015711 [organic anion transport] GO:0015721 [bile acid and bile salt transport] GO:0016020 [membrane] GO:0016323 [basolateral plasma membrane] GO:0043252 [sodium-independent organic anion transport] GO:0044281 [small molecule metabolic process] GO:0055085 [transmembrane transport] GO:0098656 [anion transmembrane transport] Show all	702 aa 77.4 kDa	No	>9