Expression of BTN3A3 in cancer - Summary - The Human Protein Atlas

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BTN3A3

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	BTN3A3
Gene description	Butyrophilin, subfamily 3, member A3
Protein class	Predicted intracellular proteins Predicted membrane proteins Predicted secreted proteins
Predicted localization	Intracellular,Membrane,Secreted
Number of transcripts	9
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (ASC TERT1, BJ hTERT+ SV40 Large T+ RasG12V)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and membranous expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Supported based on 2 antibodies. HPA007904 , HPA011871
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and ovarian cancer (favourable).
Renal cancer p<0.001 Ovarian cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA007904	HPA011871

GENE INFORMATION
Gene name	BTN3A3 (HGNC Symbol)
Synonyms	BTF3, BTN3.3
Description	Butyrophilin, subfamily 3, member A3 (HGNC Symbol)
Entrez gene summary	The butyrophilin (BTN) genes are a group of major histocompatibility complex (MHC)-associated genes that encode type I membrane proteins with 2 extracellular immunoglobulin (Ig) domains and an intracellular B30.2 (PRYSPRY) domain. Three subfamilies of human BTN genes are located in the MHC class I region: the single-copy BTN1A1 gene (MIM 601610) and the BTN2 (e.g., BTN2A1; MIM 613590) and BTN3 (e.g., BNT3A3) genes, which have undergone tandem duplication, resulting in 3 copies of each (summary by Smith et al., 2010 [PubMed 20208008]).[supplied by OMIM, Nov 2010]
Chromosome	6
Cytoband	p22.2
Chromosome location (bp)	26440472 - 26453415
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000111801 (version 83.38)
Entrez gene	10384
UniProt	O00478 (UniProt - Evidence at protein level)
neXtProt	NX_O00478
Antibodypedia	BTN3A3 antibodies

PROTEIN BROWSER

BTN3A3-001	BTN3A3-002	BTN3A3-004	BTN3A3-005	BTN3A3-006	BTN3A3-007	BTN3A3-009	BTN3A3-011	BTN3A3-013

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
BTN3A3-001 ENSP00000244519 ENST00000244519	O00478 [Direct mapping] Butyrophilin subfamily 3 member A3 A0A024R042 [Target identity:100%; Query identity:100%] Butyrophilin, subfamily 3, member A3, isoform CRA_b Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002456 [T cell mediated immunity] GO:0005515 [protein binding] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	584 aa 65 kDa	Yes	1
BTN3A3-002 ENSP00000355238 ENST00000361232	O00478 [Direct mapping] Butyrophilin subfamily 3 member A3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002456 [T cell mediated immunity] GO:0005515 [protein binding] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	535 aa 59.7 kDa	No	1
BTN3A3-004 ENSP00000417234 ENST00000494393	C9J3Q8 [Direct mapping] Butyrophilin subfamily 3 member A3 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	138 aa 15.2 kDa	Yes	0
BTN3A3-005 ENSP00000420147 ENST00000496719	C9JQT8 [Direct mapping] Butyrophilin subfamily 3 member A3 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	238 aa 25.5 kDa	Yes	0
BTN3A3-006 ENSP00000420339 ENST00000487627	C9JNZ3 [Direct mapping] Butyrophilin subfamily 3 member A3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	100 aa 11.2 kDa	No	0
BTN3A3-007 ENSP00000417717 ENST00000471353	C9J877 [Direct mapping] Butyrophilin subfamily 3 member A3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	140 aa 15.6 kDa	No	0
BTN3A3-009 ENSP00000419312 ENST00000482451	C9JVU4 [Direct mapping] Butyrophilin subfamily 3 member A3 Show all	THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	127 aa 14.1 kDa	Yes	0
BTN3A3-011 ENSP00000419736 ENST00000490254	C9JZT5 [Direct mapping] Butyrophilin subfamily 3 member A3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	210 aa 24.2 kDa	No	0
BTN3A3-013 ENSP00000419445 ENST00000487272	C9JUV8 [Direct mapping] Butyrophilin subfamily 3 member A3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	250 aa 27.3 kDa	No	1

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