Expression of MCM9 in cancer - Summary - The Human Protein Atlas

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MCM9

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	MCM9
Gene description	Minichromosome maintenance 9 homologous recombination repair factor
Protein class	Disease related genes Enzymes Potential drug targets Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Nuclear expression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA031137
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA031137

GENE INFORMATION
Gene name	MCM9 (HGNC Symbol)
Synonyms	C6orf61, dJ329L24.3, FLJ20170, MCMDC1, MGC35304
Description	Minichromosome maintenance 9 homologous recombination repair factor (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the mini-chromosome maintenance (MCM) protein family that are essential for the initiation of eukaryotic genome replication. Binding of this protein to chromatin has been shown to be a pre-requisite for recruiting the MCM2-7 helicase to DNA replication origins. This protein also binds, and is a positive regulator of, the chromatin licensing and DNA replication factor 1, CDT1. [provided by RefSeq, Nov 2010]
Chromosome	6
Cytoband	q22.31
Chromosome location (bp)	118813442 - 118935162
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000111877 (version 83.38)
Entrez gene	254394
UniProt	Q9NXL9 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NXL9
Antibodypedia	MCM9 antibodies

PROTEIN BROWSER

MCM9-001	MCM9-002	MCM9-004	MCM9-005	MCM9-008	MCM9-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MCM9-001 ENSP00000312870 ENST00000316068	Q9NXL9 [Direct mapping] DNA helicase MCM9 Show all	Enzymes ENZYME proteins Hydrolases THUMBUP predicted membrane proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0000724 [double-strand break repair via homologous recombination] GO:0003677 [DNA binding] GO:0004386 [helicase activity] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0006260 [DNA replication] GO:0006974 [cellular response to DNA damage stimulus] GO:0007292 [female gamete generation] GO:0097362 [MCM8-MCM9 complex] Show all	391 aa 44 kDa	No	0
MCM9-002 ENSP00000314505 ENST00000316316	Q9NXL9 [Direct mapping] DNA helicase MCM9 Show all	Enzymes ENZYME proteins Hydrolases THUMBUP predicted membrane proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0000724 [double-strand break repair via homologous recombination] GO:0003677 [DNA binding] GO:0004386 [helicase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0006260 [DNA replication] GO:0006974 [cellular response to DNA damage stimulus] GO:0007276 [gamete generation] GO:0007292 [female gamete generation] GO:0097362 [MCM8-MCM9 complex] Show all	1143 aa 127.3 kDa	No	0
MCM9-004 ENSP00000394776 ENST00000425154	D6RHY8 [Direct mapping] DNA helicase MCM9 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		156 aa 17.8 kDa	No	0
MCM9-005 ENSP00000426890 ENST00000505446	D6RE85 [Direct mapping] DNA helicase MCM9 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		78 aa 9 kDa	No	0
MCM9-008 ENSP00000406576 ENST00000458674	H0Y6M9 [Direct mapping] DNA helicase MCM9 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0005524 [ATP binding] GO:0006260 [DNA replication] Show all	183 aa 20.3 kDa	No	0
MCM9-201 ENSP00000480469 ENST00000619706	Q9NXL9 [Direct mapping] DNA helicase MCM9 Show all	Enzymes ENZYME proteins Hydrolases THUMBUP predicted membrane proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000724 [double-strand break repair via homologous recombination] GO:0003677 [DNA binding] GO:0004386 [helicase activity] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0006260 [DNA replication] GO:0006974 [cellular response to DNA damage stimulus] GO:0007292 [female gamete generation] GO:0097362 [MCM8-MCM9 complex] Show all	1143 aa 127.3 kDa	No	0

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The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.