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MCM9

GENERAL INFORMATION

Gene name

 MCM9

Gene description

 Minichromosome maintenance 9 homologous recombination repair factor

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Nuclear expression in several tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA031137
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 MCM9 (HGNC Symbol)

Synonyms

 C6orf61, dJ329L24.3, FLJ20170, MCMDC1, MGC35304

Description

 Minichromosome maintenance 9 homologous recombination repair factor (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the mini-chromosome maintenance (MCM) protein family that are essential for the initiation of eukaryotic genome replication. Binding of this protein to chromatin has been shown to be a pre-requisite for recruiting the MCM2-7 helicase to DNA replication origins. This protein also binds, and is a positive regulator of, the chromatin licensing and DNA replication factor 1, CDT1. [provided by RefSeq, Nov 2010]

Chromosome

 6

Cytoband

 q22.31

Chromosome location (bp)

 118813442 - 118935162

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000111877 (version 83.38)

Entrez gene

 254394

UniProt

 Q9NXL9 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NXL9

Antibodypedia

 MCM9 antibodies

PROTEIN BROWSER
MCM9-001
MCM9-002
MCM9-004
MCM9-005
MCM9-008
MCM9-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MCM9-001
ENSP00000312870
ENST00000316068
Q9NXL9 [Direct mapping]
DNA helicase MCM9
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Enzymes
   ENZYME proteins
   Hydrolases
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000724 [double-strand break repair via homologous recombination]
GO:0003677 [DNA binding]
GO:0004386 [helicase activity]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0006260 [DNA replication]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007292 [female gamete generation]
GO:0097362 [MCM8-MCM9 complex]
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 391 aa
44 kDa 		No 0
MCM9-002
ENSP00000314505
ENST00000316316
Q9NXL9 [Direct mapping]
DNA helicase MCM9
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000724 [double-strand break repair via homologous recombination]
GO:0003677 [DNA binding]
GO:0004386 [helicase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0006260 [DNA replication]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007276 [gamete generation]
GO:0007292 [female gamete generation]
GO:0097362 [MCM8-MCM9 complex]
Show all
 1143 aa
127.3 kDa 		No 0
MCM9-004
ENSP00000394776
ENST00000425154
D6RHY8 [Direct mapping]
DNA helicase MCM9
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 156 aa
17.8 kDa 		No 0
MCM9-005
ENSP00000426890
ENST00000505446
D6RE85 [Direct mapping]
DNA helicase MCM9
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 78 aa
9 kDa 		No 0
MCM9-008
ENSP00000406576
ENST00000458674
H0Y6M9 [Direct mapping]
DNA helicase MCM9
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0005524 [ATP binding]
GO:0006260 [DNA replication]
Show all
 183 aa
20.3 kDa 		No 0
MCM9-201
ENSP00000480469
ENST00000619706
Q9NXL9 [Direct mapping]
DNA helicase MCM9
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000724 [double-strand break repair via homologous recombination]
GO:0003677 [DNA binding]
GO:0004386 [helicase activity]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0006260 [DNA replication]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007292 [female gamete generation]
GO:0097362 [MCM8-MCM9 complex]
Show all
 1143 aa
127.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.