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SERINC1

GENERAL INFORMATION

Gene name

 SERINC1

Gene description

 Serine incorporator 1

Protein class

 Plasma proteins
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Mainly cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Pending external verification.

Reliability score

 Uncertain based on 2 antibodies.
HPA035738 , HPA035739
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA035738
HPA035739

GENE INFORMATION

Gene name

 SERINC1 (HGNC Symbol)

Synonyms

 KIAA1253, TDE1L, TDE2, TMS-2

Description

 Serine incorporator 1 (HGNC Symbol)

Entrez gene summary

Chromosome

 6

Cytoband

 q22.31

Chromosome location (bp)

 122443354 - 122471822

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000111897 (version 83.38)

Entrez gene

 57515

UniProt

 Q9NRX5 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NRX5

Antibodypedia

 SERINC1 antibodies

PROTEIN BROWSER
SERINC1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SERINC1-001
ENSP00000342962
ENST00000339697
Q9NRX5 [Direct mapping]
Serine incorporator 1
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005886 [plasma membrane]
GO:0006658 [phosphatidylserine metabolic process]
GO:0006665 [sphingolipid metabolic process]
GO:0008654 [phospholipid biosynthetic process]
GO:0015194 [L-serine transmembrane transporter activity]
GO:0015825 [L-serine transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0070062 [extracellular exosome]
GO:1904219 [positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity]
GO:1904222 [positive regulation of serine C-palmitoyltransferase activity]
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 453 aa
50.5 kDa 		Yes >9

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.