Expression of NCOA7 in cancer - Summary

GENERAL INFORMATION
Gene name	NCOA7
Gene description	Nuclear receptor coactivator 7
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	9
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Nuclear and cytoplasmic expression in several cell types, mainly in the CNS, squamous epithelia and peripheral nerves.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 4 antibodies. HPA030289 , HPA030290 , HPA030291 , HPA030292
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA030289	HPA030290	HPA030291	HPA030292

GENE INFORMATION
Gene name	NCOA7 (HGNC Symbol)
Synonyms	dJ187J11.3, ERAP140, TLDC4
Description	Nuclear receptor coactivator 7 (HGNC Symbol)
Entrez gene summary
Chromosome	6
Cytoband
Chromosome location (bp)	125781161 - 125932030
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000111912 (version 83.38)
Entrez gene	135112
UniProt	Q8NI08 (UniProt - Evidence at protein level)
neXtProt	NX_Q8NI08
Antibodypedia	NCOA7 antibodies

PROTEIN BROWSER

NCOA7-001	NCOA7-002	NCOA7-003	NCOA7-005	NCOA7-008	NCOA7-009	NCOA7-010	NCOA7-012	NCOA7-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NCOA7-001 ENSP00000406363 ENST00000417494	Q5TF96 [Direct mapping] Nuclear receptor coactivator 7 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		191 aa 21.7 kDa	No	0
NCOA7-002 ENSP00000398268 ENST00000438495	H0Y5F6 [Direct mapping] Nuclear receptor coactivator 7 A0A023IN41 [Target identity:100%; Query identity:100%] NCOA7-AS Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all		219 aa 25.3 kDa	No	0
NCOA7-003 ENSP00000407684 ENST00000444128	H0Y6T0 [Direct mapping] Nuclear receptor coactivator 7 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		159 aa 18.6 kDa	No	0
NCOA7-005 ENSP00000357341 ENST00000368357	Q8NI08 [Direct mapping] Nuclear receptor coactivator 7 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0030374 [ligand-dependent nuclear receptor transcription coactivator activity] GO:0035257 [nuclear hormone receptor binding] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] Show all	942 aa 106.2 kDa	No	0
NCOA7-008 ENSP00000403643 ENST00000453302	Q5TF98 [Direct mapping] Nuclear receptor coactivator 7 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		90 aa 10.7 kDa	No	0
NCOA7-009 ENSP00000407426 ENST00000428318	Q5TF98 [Direct mapping] Nuclear receptor coactivator 7 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		90 aa 10.7 kDa	No	0
NCOA7-010 ENSP00000408211 ENST00000419660	Q5TF97 [Direct mapping] Nuclear receptor coactivator 7 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		117 aa 13.9 kDa	No	0
NCOA7-012 ENSP00000229634 ENST00000229634	Q8NI08 [Direct mapping] Nuclear receptor coactivator 7 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0030374 [ligand-dependent nuclear receptor transcription coactivator activity] GO:0035257 [nuclear hormone receptor binding] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] Show all	827 aa 92.5 kDa	No	0
NCOA7-201 ENSP00000376269 ENST00000392477	Q8NI08 [Direct mapping] Nuclear receptor coactivator 7 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0030374 [ligand-dependent nuclear receptor transcription coactivator activity] GO:0035257 [nuclear hormone receptor binding] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] Show all	942 aa 106.2 kDa	No	0