Cell atlas - ULBP1 - The Human Protein Atlas

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ULBP1

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TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Actin filaments
	Cytosol
	Plasma membrane

Human cell
	Actin Filaments
	Cytosol
	Plasma Membrane

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GENERAL INFORMATION
Gene name	ULBP1
Gene description	UL16 binding protein 1
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the plasma membrane & cytosol. In addition localized to the actin filaments.
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Localized to the Plasma membrane (supported), Cytosol (approved)
Additional location	In addition localized to the Actin filaments (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA071005
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the plasma membrane & cytosol. In addition localized to the actin filaments.

Main location

Plasma membrane (supported), Cytosol (approved)

Additional location

Actin filaments (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA071005	HEK 293	Plasma membrane
	HPA071005	HEK 293	Cytosol
	HPA071005	SiHa	Plasma membrane
			Actin filaments
			Cytosol

GENE INFORMATION
Gene name	ULBP1 (HGNC Symbol)
Synonyms	RAET1I
Description	UL16 binding protein 1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a ligand of natural killer group 2, member D (NKG2D), an immune system-activating receptor on NK cells and T-cells. Binding of the encoded ligand to NKG2D leads to activation of several signal transduction pathways, including those of JAK2, STAT5, ERK and PI3K kinase/Akt. Also, in cytomegalovirus-infected cells, this ligand binds the UL16 glycoprotein and is prevented from activating the immune system. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]
Chromosome	6
Cytoband	q25.1
Chromosome location (bp)	149964007 - 149973710
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000111981 (version 83.38)
Entrez gene	80329
UniProt	Q9BZM6 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BZM6
Antibodypedia	ULBP1 antibodies

PROTEIN BROWSER

ULBP1-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ULBP1-001 ENSP00000229708 ENST00000229708	Q9BZM6 [Direct mapping] NKG2D ligand 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005783 [endoplasmic reticulum] GO:0005886 [plasma membrane] GO:0006955 [immune response] GO:0030101 [natural killer cell activation] GO:0042267 [natural killer cell mediated cytotoxicity] GO:0046658 [anchored component of plasma membrane] GO:0046703 [natural killer cell lectin-like receptor binding] GO:0050776 [regulation of immune response] Show all	244 aa 28 kDa	Yes	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.