Expression of ULBP1 in cancer - Summary - The Human Protein Atlas

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ULBP1

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ULBP1
Gene description	UL16 binding protein 1
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Mixed
HPA (normal tissue):	Tissue enhanced (testis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic membrane expression in a subset of cells in testis.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.
Reliability score	Supported based on 1 antibody. HPA007547
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA007547

GENE INFORMATION
Gene name	ULBP1 (HGNC Symbol)
Synonyms	RAET1I
Description	UL16 binding protein 1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a ligand of natural killer group 2, member D (NKG2D), an immune system-activating receptor on NK cells and T-cells. Binding of the encoded ligand to NKG2D leads to activation of several signal transduction pathways, including those of JAK2, STAT5, ERK and PI3K kinase/Akt. Also, in cytomegalovirus-infected cells, this ligand binds the UL16 glycoprotein and is prevented from activating the immune system. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]
Chromosome	6
Cytoband	q25.1
Chromosome location (bp)	149964007 - 149973710
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000111981 (version 83.38)
Entrez gene	80329
UniProt	Q9BZM6 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BZM6
Antibodypedia	ULBP1 antibodies

PROTEIN BROWSER

ULBP1-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ULBP1-001 ENSP00000229708 ENST00000229708	Q9BZM6 [Direct mapping] NKG2D ligand 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005783 [endoplasmic reticulum] GO:0005886 [plasma membrane] GO:0006955 [immune response] GO:0030101 [natural killer cell activation] GO:0042267 [natural killer cell mediated cytotoxicity] GO:0046658 [anchored component of plasma membrane] GO:0046703 [natural killer cell lectin-like receptor binding] GO:0050776 [regulation of immune response] Show all	244 aa 28 kDa	Yes	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.