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The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Q16539 [Direct mapping] Mitogen-activated protein kinase 14 L7RSM2 [Target identity:100%; Query identity:100%] Mitogen-activated protein kinase
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Enzymes ENZYME proteins Transferases Kinases CMGC Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000077 [DNA damage checkpoint] GO:0000187 [activation of MAPK activity] GO:0000902 [cell morphogenesis] GO:0000922 [spindle pole] GO:0001502 [cartilage condensation] GO:0001525 [angiogenesis] GO:0001890 [placenta development] GO:0002062 [chondrocyte differentiation] GO:0002224 [toll-like receptor signaling pathway] GO:0002755 [MyD88-dependent toll-like receptor signaling pathway] GO:0002756 [MyD88-independent toll-like receptor signaling pathway] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004707 [MAP kinase activity] GO:0004708 [MAP kinase kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005623 [cell] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005829 [cytosol] GO:0006006 [glucose metabolic process] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006468 [protein phosphorylation] GO:0006915 [apoptotic process] GO:0006928 [movement of cell or subcellular component] GO:0006935 [chemotaxis] GO:0006974 [cellular response to DNA damage stimulus] GO:0006996 [organelle organization] GO:0007005 [mitochondrion organization] GO:0007165 [signal transduction] GO:0007166 [cell surface receptor signaling pathway] GO:0007178 [transmembrane receptor protein serine/threonine kinase signaling pathway] GO:0007265 [Ras protein signal transduction] GO:0007519 [skeletal muscle tissue development] GO:0007596 [blood coagulation] GO:0008022 [protein C-terminus binding] GO:0009749 [response to glucose] GO:0010467 [gene expression] GO:0010628 [positive regulation of gene expression] GO:0010831 [positive regulation of myotube differentiation] GO:0014835 [myoblast differentiation involved in skeletal muscle regeneration] GO:0016301 [kinase activity] GO:0018105 [peptidyl-serine phosphorylation] GO:0019395 [fatty acid oxidation] GO:0019899 [enzyme binding] GO:0019903 [protein phosphatase binding] GO:0030168 [platelet activation] GO:0030316 [osteoclast differentiation] GO:0031281 [positive regulation of cyclase activity] GO:0031663 [lipopolysaccharide-mediated signaling pathway] GO:0032495 [response to muramyl dipeptide] GO:0032496 [response to lipopolysaccharide] GO:0034134 [toll-like receptor 2 signaling pathway] GO:0034138 [toll-like receptor 3 signaling pathway] GO:0034142 [toll-like receptor 4 signaling pathway] GO:0034146 [toll-like receptor 5 signaling pathway] GO:0034162 [toll-like receptor 9 signaling pathway] GO:0034166 [toll-like receptor 10 signaling pathway] GO:0035556 [intracellular signal transduction] GO:0035666 [TRIF-dependent toll-like receptor signaling pathway] GO:0035924 [cellular response to vascular endothelial growth factor stimulus] GO:0035994 [response to muscle stretch] GO:0038066 [p38MAPK cascade] GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway] GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway] GO:0042307 [positive regulation of protein import into nucleus] GO:0042692 [muscle cell differentiation] GO:0042770 [signal transduction in response to DNA damage] GO:0043488 [regulation of mRNA stability] GO:0045087 [innate immune response] GO:0045648 [positive regulation of erythrocyte differentiation] GO:0045663 [positive regulation of myoblast differentiation] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046326 [positive regulation of glucose import] GO:0046777 [protein autophosphorylation] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0051090 [regulation of sequence-specific DNA binding transcription factor activity] GO:0051146 [striated muscle cell differentiation] GO:0051149 [positive regulation of muscle cell differentiation] GO:0051403 [stress-activated MAPK cascade] GO:0051525 [NFAT protein binding] GO:0060045 [positive regulation of cardiac muscle cell proliferation] GO:0070062 [extracellular exosome] GO:0070935 [3'-UTR-mediated mRNA stabilization] GO:0071222 [cellular response to lipopolysaccharide] GO:0071479 [cellular response to ionizing radiation] GO:0090090 [negative regulation of canonical Wnt signaling pathway] GO:0090336 [positive regulation of brown fat cell differentiation] GO:0090400 [stress-induced premature senescence] GO:0098586 [cellular response to virus] GO:1900015 [regulation of cytokine production involved in inflammatory response] GO:1901741 [positive regulation of myoblast fusion] GO:2000379 [positive regulation of reactive oxygen species metabolic process] GO:2001184 [positive regulation of interleukin-12 secretion]
Q16539 [Direct mapping] Mitogen-activated protein kinase 14 A0A024RD15 [Target identity:100%; Query identity:100%] Mitogen-activated protein kinase
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Enzymes ENZYME proteins Transferases Kinases CMGC Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Q16539 [Direct mapping] Mitogen-activated protein kinase 14
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Enzymes ENZYME proteins Transferases Kinases CMGC Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)