Several cases of colorectal, prostate, testicular, breast, stomach, liver, pancreatic cancers along with few cases of melanomas, lymphomas, cervical, thyroid, lung and skin cancers displayed moderate to strong cytoplasmic and/or nucleolar staining. Remaining cancer tissues were weakly stained or negative.
RNF8 (HGNC Symbol)
Ring finger protein 8, E3 ubiquitin protein ligase (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene contains a RING finger motif and an FHA domain. This protein has been shown to interact with several class II ubiquitin-conjugating enzymes (E2), including UBE2E1/UBCH6, UBE2E2, and UBE2E3, and may act as an ubiquitin ligase (E3) in the ubiquitination of certain nuclear proteins. This protein is also known to play a role in the DNA damage response and depletion of this protein causes cell growth inhibition and cell cycle arrest. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]