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GENERAL INFORMATION

Gene name

 ICK

Gene description

 Intestinal cell (MAK-like) kinase

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in several tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA001113
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 ICK (HGNC Symbol)

Synonyms

 KIAA0936, LCK2, MGC46090, MRK

Description

 Intestinal cell (MAK-like) kinase (HGNC Symbol)

Entrez gene summary

 Eukaryotic protein kinases are enzymes that belong to a very extensive family of proteins which share a conserved catalytic core common with both serine/threonine and tyrosine protein kinases. This gene encodes an intestinal serine/threonine kinase harboring a dual phosphorylation site found in mitogen-activating protein (MAP) kinases. The protein localizes to the intestinal crypt region and is thought to be important in intestinal epithelial cell proliferation and differentiation. Alternative splicing has been observed at this locus and two variants, encoding the same isoform, have been identified. [provided by RefSeq, Jul 2008]

Chromosome

 6

Cytoband

 p12.1

Chromosome location (bp)

 53001279 - 53061802

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000112144 (version 83.38)

Entrez gene

 22858

UniProt

 Q9UPZ9 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UPZ9

Antibodypedia

 ICK antibodies

PROTEIN BROWSER
ICK-001
ICK-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ICK-001
ENSP00000263043
ENST00000350082
Q9UPZ9 [Direct mapping]
Serine/threonine-protein kinase ICK
A0A024RD59 [Target identity:100%; Query identity:100%]
Intestinal cell (MAK-like) kinase, isoform CRA_a
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CMGC Ser/Thr protein kinases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Show all
GO:0000287 [magnesium ion binding]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004693 [cyclin-dependent protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0007165 [signal transduction]
GO:0007275 [multicellular organismal development]
GO:0035556 [intracellular signal transduction]
GO:0036064 [ciliary basal body]
GO:0042073 [intraciliary transport]
GO:0042384 [cilium assembly]
GO:0051726 [regulation of cell cycle]
GO:0097542 [ciliary tip]
Show all
 632 aa
71.4 kDa 		No 0
ICK-201
ENSP00000349458
ENST00000356971
Q9UPZ9 [Direct mapping]
Serine/threonine-protein kinase ICK
A0A024RD59 [Target identity:100%; Query identity:100%]
Intestinal cell (MAK-like) kinase, isoform CRA_a
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CMGC Ser/Thr protein kinases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Show all
GO:0000287 [magnesium ion binding]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004693 [cyclin-dependent protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0007165 [signal transduction]
GO:0007275 [multicellular organismal development]
GO:0035556 [intracellular signal transduction]
GO:0036064 [ciliary basal body]
GO:0042073 [intraciliary transport]
GO:0042384 [cilium assembly]
GO:0051726 [regulation of cell cycle]
GO:0097542 [ciliary tip]
Show all
 632 aa
71.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.