Expression of CAP2 in cancer - Summary - The Human Protein Atlas

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CAP2

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CAP2
Gene description	CAP, adenylate cyclase-associated protein, 2 (yeast)
Protein class	Cancer-related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Tissue enhanced (cerebral cortex, skeletal muscle)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in the CNS, myocytes and smooth muscle cells.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA050530 , HPA054147
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA050530	HPA054147

GENE INFORMATION
Gene name	CAP2
Synonyms
Description	CAP, adenylate cyclase-associated protein, 2 (yeast) (HGNC Symbol)
Entrez gene summary	This gene was identified by its similarity to the gene for human adenylyl cyclase-associated protein. The function of the protein encoded by this gene is unknown. However, the protein appears to be able to interact with adenylyl cyclase-associated protein and actin. [provided by RefSeq, Jul 2008]
Chromosome	6
Cytoband	p22.3
Chromosome location (bp)	17393216 - 17557792
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000112186 (version 83.38)
Entrez gene	10486
UniProt	P40123 (UniProt - Evidence at protein level)
neXtProt	NX_P40123
Antibodypedia	CAP2 antibodies

PROTEIN BROWSER

CAP2-001	CAP2-003	CAP2-004	CAP2-006	CAP2-007	CAP2-201	CAP2-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CAP2-001 ENSP00000229922 ENST00000229922	P40123 [Direct mapping] Adenylyl cyclase-associated protein 2 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003779 [actin binding] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0007010 [cytoskeleton organization] GO:0007163 [establishment or maintenance of cell polarity] GO:0007165 [signal transduction] GO:0007190 [activation of adenylate cyclase activity] GO:0007411 [axon guidance] GO:0097481 [neuronal postsynaptic density] Show all	477 aa 52.8 kDa	No	0
CAP2-003 ENSP00000417705 ENST00000489374	B7Z385 [Direct mapping] Adenylyl cyclase-associated protein Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0000902 [cell morphogenesis] GO:0003779 [actin binding] GO:0007010 [cytoskeleton organization] Show all	365 aa 39.9 kDa	No	0
CAP2-004 ENSP00000417208 ENST00000493172	P40123 [Direct mapping] Adenylyl cyclase-associated protein 2 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0003779 [actin binding] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0007010 [cytoskeleton organization] GO:0007163 [establishment or maintenance of cell polarity] GO:0007165 [signal transduction] GO:0007190 [activation of adenylate cyclase activity] GO:0007411 [axon guidance] Show all	217 aa 24 kDa	No	0
CAP2-006 ENSP00000368275 ENST00000378990	E9PDI2 [Direct mapping] Adenylyl cyclase-associated protein Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0000902 [cell morphogenesis] GO:0003779 [actin binding] GO:0007010 [cytoskeleton organization] Show all	451 aa 49.8 kDa	No	0
CAP2-007 ENSP00000418604 ENST00000465994	P40123 [Direct mapping] Adenylyl cyclase-associated protein 2 Show all	MEMSAT3 predicted membrane proteins Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0003779 [actin binding] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0007010 [cytoskeleton organization] GO:0007163 [establishment or maintenance of cell polarity] GO:0007165 [signal transduction] GO:0007190 [activation of adenylate cyclase activity] GO:0007411 [axon guidance] Show all	413 aa 45.2 kDa	No	0
CAP2-201 ENSP00000482279 ENST00000611958	A0A087WZ15 [Direct mapping] Adenylyl cyclase-associated protein Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0000902 [cell morphogenesis] GO:0003779 [actin binding] GO:0007010 [cytoskeleton organization] Show all	394 aa 43.6 kDa	No	0
CAP2-202 ENSP00000483435 ENST00000616440	A0A087X0J3 [Direct mapping] Adenylyl cyclase-associated protein Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0000902 [cell morphogenesis] GO:0003779 [actin binding] GO:0007010 [cytoskeleton organization] Show all	394 aa 43.5 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.