Tissue expression of CAP2 - Summary - The Human Protein Atlas

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CAP2

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TISSUE

CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	CAP2
Gene description	CAP, adenylate cyclase-associated protein, 2 (yeast)
Protein class	Cancer-related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (cerebral cortex, skeletal muscle)
GTEx:	Expressed in all
FANTOM5:	Tissue enhanced (skeletal muscle)

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in the CNS, myocytes and smooth muscle cells.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA050530 , HPA054147
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (cerebral cortex, skeletal muscle)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (skeletal muscle)

GENE INFORMATION
Gene name	CAP2
Synonyms
Description	CAP, adenylate cyclase-associated protein, 2 (yeast) (HGNC Symbol)
Entrez gene summary	This gene was identified by its similarity to the gene for human adenylyl cyclase-associated protein. The function of the protein encoded by this gene is unknown. However, the protein appears to be able to interact with adenylyl cyclase-associated protein and actin. [provided by RefSeq, Jul 2008]
Chromosome	6
Cytoband	p22.3
Chromosome location (bp)	17393216 - 17557792
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000112186 (version 83.38)
Entrez gene	10486
UniProt	P40123 (UniProt - Evidence at protein level)
neXtProt	NX_P40123
Antibodypedia	CAP2 antibodies

PROTEIN BROWSER

CAP2-001	CAP2-003	CAP2-004	CAP2-006	CAP2-007	CAP2-201	CAP2-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CAP2-001 ENSP00000229922 ENST00000229922	P40123 [Direct mapping] Adenylyl cyclase-associated protein 2 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003779 [actin binding] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0007010 [cytoskeleton organization] GO:0007163 [establishment or maintenance of cell polarity] GO:0007165 [signal transduction] GO:0007190 [activation of adenylate cyclase activity] GO:0007411 [axon guidance] GO:0097481 [neuronal postsynaptic density] Show all	477 aa 52.8 kDa	No	0
CAP2-003 ENSP00000417705 ENST00000489374	B7Z385 [Direct mapping] Adenylyl cyclase-associated protein Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0000902 [cell morphogenesis] GO:0003779 [actin binding] GO:0007010 [cytoskeleton organization] Show all	365 aa 39.9 kDa	No	0
CAP2-004 ENSP00000417208 ENST00000493172	P40123 [Direct mapping] Adenylyl cyclase-associated protein 2 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0003779 [actin binding] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0007010 [cytoskeleton organization] GO:0007163 [establishment or maintenance of cell polarity] GO:0007165 [signal transduction] GO:0007190 [activation of adenylate cyclase activity] GO:0007411 [axon guidance] Show all	217 aa 24 kDa	No	0
CAP2-006 ENSP00000368275 ENST00000378990	E9PDI2 [Direct mapping] Adenylyl cyclase-associated protein Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0000902 [cell morphogenesis] GO:0003779 [actin binding] GO:0007010 [cytoskeleton organization] Show all	451 aa 49.8 kDa	No	0
CAP2-007 ENSP00000418604 ENST00000465994	P40123 [Direct mapping] Adenylyl cyclase-associated protein 2 Show all	MEMSAT3 predicted membrane proteins Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0003779 [actin binding] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0007010 [cytoskeleton organization] GO:0007163 [establishment or maintenance of cell polarity] GO:0007165 [signal transduction] GO:0007190 [activation of adenylate cyclase activity] GO:0007411 [axon guidance] Show all	413 aa 45.2 kDa	No	0
CAP2-201 ENSP00000482279 ENST00000611958	A0A087WZ15 [Direct mapping] Adenylyl cyclase-associated protein Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0000902 [cell morphogenesis] GO:0003779 [actin binding] GO:0007010 [cytoskeleton organization] Show all	394 aa 43.6 kDa	No	0
CAP2-202 ENSP00000483435 ENST00000616440	A0A087X0J3 [Direct mapping] Adenylyl cyclase-associated protein Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0000902 [cell morphogenesis] GO:0003779 [actin binding] GO:0007010 [cytoskeleton organization] Show all	394 aa 43.5 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.