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Most malignant cells showed weak to moderate cytoplasmic staining. Nuclear positivity was observed in several cases. Most cases of squamous cell carcinomas, renal and endometrial cancers were negative.
Most malignant tissues showed weak to moderate cytoplasmic and nuclear positivity. Several cervical, endometrial and testicular cancers were strongly stained.
GENE INFORMATION
Gene name
WASF1 (HGNC Symbol)
Synonyms
KIAA0269, SCAR1, WAVE, WAVE1
Description
WAS protein family, member 1 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene, a member of the Wiskott-Aldrich syndrome protein (WASP)-family, plays a critical role downstream of Rac, a Rho-family small GTPase, in regulating the actin cytoskeleton required for membrane ruffling. It has been shown to associate with an actin nucleation core Arp2/3 complex while enhancing actin polymerization in vitro. Wiskott-Aldrich syndrome is a disease of the immune system, likely due to defects in regulation of actin cytoskeleton. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]