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WASF1

GENERAL INFORMATION

Gene name

 WASF1

Gene description

 WAS protein family, member 1

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 10
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Group enriched (cerebral cortex, testis)
GTEx:Expressed in all
FANTOM5:Group enriched (brain, caudate, cerebellum, hippocampus, pituitary gland, testis)

Protein evidence

 Evidence at protein level

Protein expression

 Ubiquitous cytoplasmic expression, highly expressed in CNS.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 2 antibodies.
HPA004105 , CAB022161
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (cerebral cortex, testis)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (brain, caudate, cerebellum, hippocampus, pituitary gland, testis)

GENE INFORMATION

Gene name

 WASF1 (HGNC Symbol)

Synonyms

 KIAA0269, SCAR1, WAVE, WAVE1

Description

 WAS protein family, member 1 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene, a member of the Wiskott-Aldrich syndrome protein (WASP)-family, plays a critical role downstream of Rac, a Rho-family small GTPase, in regulating the actin cytoskeleton required for membrane ruffling. It has been shown to associate with an actin nucleation core Arp2/3 complex while enhancing actin polymerization in vitro. Wiskott-Aldrich syndrome is a disease of the immune system, likely due to defects in regulation of actin cytoskeleton. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 6

Cytoband

 q21

Chromosome location (bp)

 110099819 - 110180004

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000112290 (version 83.38)

Entrez gene

 8936

UniProt

 Q92558 (UniProt - Evidence at protein level)

neXtProt

 NX_Q92558

Antibodypedia

 WASF1 antibodies

PROTEIN BROWSER
WASF1-001
WASF1-002
WASF1-003
WASF1-004
WASF1-005
WASF1-006
WASF1-007
WASF1-201
WASF1-202
WASF1-203

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
WASF1-001
ENSP00000265601
ENST00000265601
Q5SZK4 [Direct mapping]
Wiskott-Aldrich syndrome protein family member 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005856 [cytoskeleton]
GO:0030036 [actin cytoskeleton organization]
Show all
 140 aa
16.2 kDa 		No 0
WASF1-002
ENSP00000376365
ENST00000392586
Q92558 [Direct mapping]
Wiskott-Aldrich syndrome protein family member 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005856 [cytoskeleton]
GO:0005925 [focal adhesion]
GO:0006461 [protein complex assembly]
GO:0006928 [movement of cell or subcellular component]
GO:0015629 [actin cytoskeleton]
GO:0016601 [Rac protein signal transduction]
GO:0030041 [actin filament polymerization]
GO:0031209 [SCAR complex]
GO:0032403 [protein complex binding]
GO:0045202 [synapse]
GO:0048365 [Rac GTPase binding]
GO:2000601 [positive regulation of Arp2/3 complex-mediated actin nucleation]
Show all
 559 aa
61.7 kDa 		No 0
WASF1-003
ENSP00000404142
ENST00000419252
Q5SZK3 [Direct mapping]
Wiskott-Aldrich syndrome protein family member 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005856 [cytoskeleton]
GO:0030036 [actin cytoskeleton organization]
Show all
 89 aa
10.2 kDa 		No 0
WASF1-004
ENSP00000376366
ENST00000392587
Q92558 [Direct mapping]
Wiskott-Aldrich syndrome protein family member 1
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005856 [cytoskeleton]
GO:0005925 [focal adhesion]
GO:0006461 [protein complex assembly]
GO:0006928 [movement of cell or subcellular component]
GO:0015629 [actin cytoskeleton]
GO:0016601 [Rac protein signal transduction]
GO:0030041 [actin filament polymerization]
GO:0031209 [SCAR complex]
GO:0032403 [protein complex binding]
GO:0045202 [synapse]
GO:0048365 [Rac GTPase binding]
GO:2000601 [positive regulation of Arp2/3 complex-mediated actin nucleation]
Show all
 559 aa
61.7 kDa 		No 0
WASF1-005
ENSP00000407041
ENST00000444391
Q5SZK5 [Direct mapping]
Wiskott-Aldrich syndrome protein family member 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005856 [cytoskeleton]
GO:0030036 [actin cytoskeleton organization]
Show all
 180 aa
21.2 kDa 		No 0
WASF1-006
ENSP00000402663
ENST00000447287
Q5SZK3 [Direct mapping]
Wiskott-Aldrich syndrome protein family member 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005856 [cytoskeleton]
GO:0030036 [actin cytoskeleton organization]
Show all
 89 aa
10.2 kDa 		No 0
WASF1-007
ENSP00000357934
ENST00000368938
Q5SZK4 [Direct mapping]
Wiskott-Aldrich syndrome protein family member 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005856 [cytoskeleton]
GO:0030036 [actin cytoskeleton organization]
Show all
 140 aa
16.2 kDa 		No 0
WASF1-201
ENSP00000352425
ENST00000359451
Q92558 [Direct mapping]
Wiskott-Aldrich syndrome protein family member 1
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005856 [cytoskeleton]
GO:0005925 [focal adhesion]
GO:0006461 [protein complex assembly]
GO:0006928 [movement of cell or subcellular component]
GO:0015629 [actin cytoskeleton]
GO:0016601 [Rac protein signal transduction]
GO:0030041 [actin filament polymerization]
GO:0031209 [SCAR complex]
GO:0032403 [protein complex binding]
GO:0045202 [synapse]
GO:0048365 [Rac GTPase binding]
GO:2000601 [positive regulation of Arp2/3 complex-mediated actin nucleation]
Show all
 559 aa
61.7 kDa 		No 0
WASF1-202
ENSP00000376367
ENST00000392588
Q92558 [Direct mapping]
Wiskott-Aldrich syndrome protein family member 1
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005856 [cytoskeleton]
GO:0005925 [focal adhesion]
GO:0006461 [protein complex assembly]
GO:0006928 [movement of cell or subcellular component]
GO:0015629 [actin cytoskeleton]
GO:0016601 [Rac protein signal transduction]
GO:0030041 [actin filament polymerization]
GO:0031209 [SCAR complex]
GO:0032403 [protein complex binding]
GO:0045202 [synapse]
GO:0048365 [Rac GTPase binding]
GO:2000601 [positive regulation of Arp2/3 complex-mediated actin nucleation]
Show all
 559 aa
61.7 kDa 		No 0
WASF1-203
ENSP00000376368
ENST00000392589
Q92558 [Direct mapping]
Wiskott-Aldrich syndrome protein family member 1
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0005856 [cytoskeleton]
GO:0005925 [focal adhesion]
GO:0006461 [protein complex assembly]
GO:0006928 [movement of cell or subcellular component]
GO:0015629 [actin cytoskeleton]
GO:0016601 [Rac protein signal transduction]
GO:0030027 [lamellipodium]
GO:0030041 [actin filament polymerization]
GO:0031209 [SCAR complex]
GO:0032403 [protein complex binding]
GO:0045202 [synapse]
GO:0048365 [Rac GTPase binding]
GO:0072673 [lamellipodium morphogenesis]
GO:2000601 [positive regulation of Arp2/3 complex-mediated actin nucleation]
Show all
 559 aa
61.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.