Fields »
ABOUT
HELP
BLOG
VNN1

GENERAL INFORMATION

Gene name

 VNN1

Gene description

 Vanin 1

Protein class

 Enzymes
Plasma proteins
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 1
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Group enriched (duodenum, gallbladder, liver, small intestine)
GTEx:Tissue enhanced (liver, small intestine)
FANTOM5:Group enriched (colon, liver, small intestine)

Protein evidence

 Evidence at protein level

Protein expression

 Membranous and cytoplasmic expression in several tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA064145
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Duodenum

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (duodenum, gallbladder, liver, small intestine)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (liver, small intestine)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (colon, liver, small intestine)

GENE INFORMATION

Gene name

 VNN1 (HGNC Symbol)

Synonyms

 Tiff66

Description

 Vanin 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the vanin family of proteins, which share extensive sequence similarity with each other, and also with biotinidase. The family includes secreted and membrane-associated proteins, a few of which have been reported to participate in hematopoietic cell trafficking. No biotinidase activity has been demonstrated for any of the vanin proteins, however, they possess pantetheinase activity, which may play a role in oxidative-stress response. This protein, like its mouse homolog, is likely a GPI-anchored cell surface molecule. The mouse protein is expressed by the perivascular thymic stromal cells and regulates migration of T-cell progenitors to the thymus. This gene lies in close proximity to, and in the same transcriptional orientation as, two other vanin genes on chromosome 6q23-q24. [provided by RefSeq, Feb 2009]

Chromosome

 6

Cytoband

 q23.2

Chromosome location (bp)

 132681590 - 132714049

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000112299 (version 83.38)

Entrez gene

 8876

UniProt

 O95497 (UniProt - Evidence at protein level)

neXtProt

 NX_O95497

Antibodypedia

 VNN1 antibodies

PROTEIN BROWSER
VNN1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
VNN1-001
ENSP00000356905
ENST00000367928
O95497 [Direct mapping]
Pantetheinase
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002526 [acute inflammatory response]
GO:0002544 [chronic inflammatory response]
GO:0005886 [plasma membrane]
GO:0006807 [nitrogen compound metabolic process]
GO:0006928 [movement of cell or subcellular component]
GO:0006954 [inflammatory response]
GO:0006979 [response to oxidative stress]
GO:0015939 [pantothenate metabolic process]
GO:0016021 [integral component of membrane]
GO:0016337 [single organismal cell-cell adhesion]
GO:0016810 [hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds]
GO:0016811 [hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides]
GO:0017159 [pantetheine hydrolase activity]
GO:0031225 [anchored component of membrane]
GO:0033089 [positive regulation of T cell differentiation in thymus]
GO:0034235 [GPI anchor binding]
GO:0045087 [innate immune response]
GO:0070062 [extracellular exosome]
GO:1902176 [negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway]
Show all
 513 aa
57 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.