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PDE10A

GENERAL INFORMATION

Gene name

 PDE10A

Gene description

 Phosphodiesterase 10A

Protein class

 Enzymes
FDA approved drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enhanced (LHCN-M2, TIME)
HPA (normal tissue):Tissue enhanced (thyroid gland)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Positivity in processes in caudate.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Presumed off target binding observed and disregarded. GTEx data supports antibody staining in caudate.

Reliability score

 Supported based on 2 antibodies.
HPA047200 , CAB045998
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA047200
CAB045998

GENE INFORMATION

Gene name

 PDE10A

Synonyms

Description

 Phosphodiesterase 10A (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase family. It plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This protein can hydrolyze both cAMP and cGMP to the corresponding nucleoside 5' monophosphate, but has higher affinity for cAMP, and is more efficient with cAMP as substrate. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Dec 2011]

Chromosome

 6

Cytoband

 q27

Chromosome location (bp)

 165327287 - 165986603

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000112541 (version 83.38)

Entrez gene

 10846

UniProt

 Q9Y233 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9Y233

Antibodypedia

 PDE10A antibodies

PROTEIN BROWSER
PDE10A-001
PDE10A-002
PDE10A-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PDE10A-001
ENSP00000355847
ENST00000366882
Q9Y233 [Direct mapping]
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
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Enzymes
   ENZYME proteins
   Hydrolases
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
FDA approved drug targets
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
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GO:0004114 [3',5'-cyclic-nucleotide phosphodiesterase activity]
GO:0004118 [cGMP-stimulated cyclic-nucleotide phosphodiesterase activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0006198 [cAMP catabolic process]
GO:0007165 [signal transduction]
GO:0007596 [blood coagulation]
GO:0008081 [phosphoric diester hydrolase activity]
GO:0030552 [cAMP binding]
GO:0030553 [cGMP binding]
GO:0046069 [cGMP catabolic process]
GO:0046872 [metal ion binding]
GO:0047555 [3',5'-cyclic-GMP phosphodiesterase activity]
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 779 aa
88.4 kDa 		No 0
PDE10A-002
ENSP00000438284
ENST00000539869
Q9Y233 [Direct mapping]
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
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Enzymes
   ENZYME proteins
   Hydrolases
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0004112 [cyclic-nucleotide phosphodiesterase activity]
GO:0004114 [3',5'-cyclic-nucleotide phosphodiesterase activity]
GO:0004118 [cGMP-stimulated cyclic-nucleotide phosphodiesterase activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0006198 [cAMP catabolic process]
GO:0007165 [signal transduction]
GO:0007596 [blood coagulation]
GO:0008081 [phosphoric diester hydrolase activity]
GO:0008144 [drug binding]
GO:0010738 [regulation of protein kinase A signaling]
GO:0016020 [membrane]
GO:0030552 [cAMP binding]
GO:0030553 [cGMP binding]
GO:0043025 [neuronal cell body]
GO:0043204 [perikaryon]
GO:0043949 [regulation of cAMP-mediated signaling]
GO:0046069 [cGMP catabolic process]
GO:0046872 [metal ion binding]
GO:0047555 [3',5'-cyclic-GMP phosphodiesterase activity]
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 789 aa
89.4 kDa 		No 0
PDE10A-201
ENSP00000478556
ENST00000616273
A0A087WUD0 [Direct mapping]
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 183 aa
19.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.