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BYSL

GENERAL INFORMATION

Gene name

 BYSL

Gene description

 Bystin-like

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous nucleolar expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA031217 , HPA031219
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and liver cancer (unfavourable).
Renal cancer p<0.001
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA031217
HPA031219

GENE INFORMATION

Gene name

 BYSL

Synonyms

Description

 Bystin-like (HGNC Symbol)

Entrez gene summary

 Bystin is expressed as a 2-kb major transcript and a 3.6-kb minor transcript in SNG-M cells and in human trophoblastic teratocarcinoma HT-H cells. Protein binding assays determined that bystin binds directly to trophinin and tastin, and that binding is enhanced when cytokeratins 8 and 18 are present. Immunocytochemistry of HT-H cells showed that bystin colocalizes with trophinin, tastin, and the cytokeratins, suggesting that these molecules form a complex in trophectoderm cells at the time of implantation. Using immunohistochemistry it was determined that trophinin and bystin are found in the placenta from the sixth week of pregnancy. Both proteins were localized in the cytoplasm of the syncytiotrophoblast in the chorionic villi and in endometrial decidual cells at the uteroplacental interface. After week 10, the levels of trophinin, tastin, and bystin decreased and then disappeared from placental villi. [provided by RefSeq, Jul 2008]

Chromosome

 6

Cytoband

 p21.1

Chromosome location (bp)

 41921188 - 41933046

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000112578 (version 83.38)

Entrez gene

 705

UniProt

 Q13895 (UniProt - Evidence at protein level)

neXtProt

 NX_Q13895

Antibodypedia

 BYSL antibodies

PROTEIN BROWSER
BYSL-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
BYSL-001
ENSP00000230340
ENST00000230340
Q13895 [Direct mapping]
Bystin
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000462 [maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)]
GO:0001701 [in utero embryonic development]
GO:0001825 [blastocyst formation]
GO:0001829 [trophectodermal cell differentiation]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005881 [cytoplasmic microtubule]
GO:0007155 [cell adhesion]
GO:0007420 [brain development]
GO:0007565 [female pregnancy]
GO:0008283 [cell proliferation]
GO:0016020 [membrane]
GO:0030182 [neuron differentiation]
GO:0042995 [cell projection]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0044822 [poly(A) RNA binding]
GO:0045177 [apical part of cell]
GO:0048471 [perinuclear region of cytoplasm]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0071347 [cellular response to interleukin-1]
GO:0071363 [cellular response to growth factor stimulus]
GO:0071407 [cellular response to organic cyclic compound]
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 437 aa
49.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.