Expression of PTK7 in cancer - Summary - The Human Protein Atlas

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PTK7

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	PTK7
Gene description	Protein tyrosine kinase 7 (inactive)
Protein class	Enzymes Plasma proteins Predicted intracellular proteins Predicted membrane proteins Predicted secreted proteins
Predicted localization	Intracellular,Membrane,Secreted
Number of transcripts	10
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA003222
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA003222

GENE INFORMATION
Gene name	PTK7 (HGNC Symbol)
Synonyms	CCK4
Description	Protein tyrosine kinase 7 (inactive) (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the receptor protein tyrosine kinase family of proteins that transduce extracellular signals across the cell membrane. The encoded protein lacks detectable catalytic tyrosine kinase activity, is involved in the Wnt signaling pathway and plays a role in multiple cellular processes including polarity and adhesion. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
Chromosome	6
Cytoband	p21.1
Chromosome location (bp)	43076268 - 43161719
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000112655 (version 83.38)
Entrez gene	5754
UniProt	Q13308 (UniProt - Evidence at protein level)
neXtProt	NX_Q13308
Antibodypedia	PTK7 antibodies

PROTEIN BROWSER

PTK7-001	PTK7-003	PTK7-004	PTK7-005	PTK7-006	PTK7-009	PTK7-012	PTK7-013	PTK7-015	PTK7-020

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PTK7-001 ENSP00000230419 ENST00000230419	Q13308 [Direct mapping] Inactive tyrosine-protein kinase 7 Show all	Enzymes Kinases Tyr protein kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001736 [establishment of planar polarity] GO:0003401 [axis elongation] GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005887 [integral component of plasma membrane] GO:0005911 [cell-cell junction] GO:0005925 [focal adhesion] GO:0006468 [protein phosphorylation] GO:0007155 [cell adhesion] GO:0007165 [signal transduction] GO:0010976 [positive regulation of neuron projection development] GO:0016477 [cell migration] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0031532 [actin cytoskeleton reorganization] GO:0060070 [canonical Wnt signaling pathway] GO:0071300 [cellular response to retinoic acid] Show all	1070 aa 118.4 kDa	Yes	1
PTK7-003 ENSP00000419037 ENST00000471863	Q86X91 [Direct mapping] Inactive tyrosine-protein kinase 7; PTK7 protein Show all	TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001736 [establishment of planar polarity] GO:0003401 [axis elongation] GO:0005515 [protein binding] Show all	459 aa 50.4 kDa	Yes	0
PTK7-004 ENSP00000325462 ENST00000349241	Q13308 [Direct mapping] Inactive tyrosine-protein kinase 7 Show all	Enzymes Kinases Tyr protein kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001736 [establishment of planar polarity] GO:0003401 [axis elongation] GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005887 [integral component of plasma membrane] GO:0005911 [cell-cell junction] GO:0005925 [focal adhesion] GO:0006468 [protein phosphorylation] GO:0007155 [cell adhesion] GO:0007165 [signal transduction] GO:0010976 [positive regulation of neuron projection development] GO:0016477 [cell migration] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0031532 [actin cytoskeleton reorganization] GO:0060070 [canonical Wnt signaling pathway] GO:0071300 [cellular response to retinoic acid] Show all	940 aa 103.6 kDa	Yes	1
PTK7-005 ENSP00000326029 ENST00000352931	Q13308 [Direct mapping] Inactive tyrosine-protein kinase 7 Show all	Enzymes Kinases Tyr protein kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001736 [establishment of planar polarity] GO:0003401 [axis elongation] GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005887 [integral component of plasma membrane] GO:0005911 [cell-cell junction] GO:0005925 [focal adhesion] GO:0006468 [protein phosphorylation] GO:0007155 [cell adhesion] GO:0007165 [signal transduction] GO:0010976 [positive regulation of neuron projection development] GO:0016477 [cell migration] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0031532 [actin cytoskeleton reorganization] GO:0060070 [canonical Wnt signaling pathway] GO:0071300 [cellular response to retinoic acid] Show all	1014 aa 112.3 kDa	Yes	1
PTK7-006 ENSP00000325992 ENST00000345201	Q13308 [Direct mapping] Inactive tyrosine-protein kinase 7 Show all	Enzymes Kinases Tyr protein kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001736 [establishment of planar polarity] GO:0003401 [axis elongation] GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005887 [integral component of plasma membrane] GO:0005911 [cell-cell junction] GO:0005925 [focal adhesion] GO:0006468 [protein phosphorylation] GO:0007155 [cell adhesion] GO:0007165 [signal transduction] GO:0010976 [positive regulation of neuron projection development] GO:0016477 [cell migration] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0031532 [actin cytoskeleton reorganization] GO:0060070 [canonical Wnt signaling pathway] GO:0071300 [cellular response to retinoic acid] Show all	1030 aa 113.8 kDa	Yes	1
PTK7-009 ENSP00000418754 ENST00000481273	Q13308 [Direct mapping] Inactive tyrosine-protein kinase 7 Show all	Enzymes Kinases Tyr protein kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001736 [establishment of planar polarity] GO:0001843 [neural tube closure] GO:0003281 [ventricular septum development] GO:0003401 [axis elongation] GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0005911 [cell-cell junction] GO:0005925 [focal adhesion] GO:0006468 [protein phosphorylation] GO:0007155 [cell adhesion] GO:0007165 [signal transduction] GO:0007507 [heart development] GO:0010976 [positive regulation of neuron projection development] GO:0016020 [membrane] GO:0016477 [cell migration] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0031532 [actin cytoskeleton reorganization] GO:0042060 [wound healing] GO:0045198 [establishment of epithelial cell apical/basal polarity] GO:0060026 [convergent extension] GO:0060070 [canonical Wnt signaling pathway] GO:0060484 [lung-associated mesenchyme development] GO:0060976 [coronary vasculature development] GO:0071300 [cellular response to retinoic acid] GO:0090103 [cochlea morphogenesis] GO:0090179 [planar cell polarity pathway involved in neural tube closure] Show all	1078 aa 119.2 kDa	No	1
PTK7-012 ENSP00000420765 ENST00000489707	H0Y8F1 [Direct mapping] Inactive tyrosine-protein kinase 7 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001736 [establishment of planar polarity] GO:0003401 [axis elongation] GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] GO:0016021 [integral component of membrane] GO:0018108 [peptidyl-tyrosine phosphorylation] Show all	365 aa 40.9 kDa	No	0
PTK7-013 ENSP00000417607 ENST00000476760	C9J9E8 [Direct mapping] Inactive tyrosine-protein kinase 7 Show all	TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001736 [establishment of planar polarity] GO:0003401 [axis elongation] GO:0005515 [protein binding] Show all	139 aa 14.9 kDa	Yes	0
PTK7-015 ENSP00000420165 ENST00000481946	H7C5L0 [Direct mapping] Inactive tyrosine-protein kinase 7 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001736 [establishment of planar polarity] GO:0003401 [axis elongation] GO:0005515 [protein binding] Show all	269 aa 29.9 kDa	No	0
PTK7-020 ENSP00000420186 ENST00000473339	C9JQR6 [Direct mapping] Inactive tyrosine-protein kinase 7 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001736 [establishment of planar polarity] GO:0003401 [axis elongation] GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	257 aa 28.6 kDa	Yes	0

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The Human Protein Atlas

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