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PTK7

GENERAL INFORMATION

Gene name

 PTK7

Gene description

 Protein tyrosine kinase 7 (inactive)

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Membrane,Secreted

Number of transcripts

 10
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Mixed
FANTOM5:Mixed

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in several tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA003222
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed

GENE INFORMATION

Gene name

 PTK7 (HGNC Symbol)

Synonyms

 CCK4

Description

 Protein tyrosine kinase 7 (inactive) (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the receptor protein tyrosine kinase family of proteins that transduce extracellular signals across the cell membrane. The encoded protein lacks detectable catalytic tyrosine kinase activity, is involved in the Wnt signaling pathway and plays a role in multiple cellular processes including polarity and adhesion. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]

Chromosome

 6

Cytoband

 p21.1

Chromosome location (bp)

 43076268 - 43161719

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000112655 (version 83.38)

Entrez gene

 5754

UniProt

 Q13308 (UniProt - Evidence at protein level)

neXtProt

 NX_Q13308

Antibodypedia

 PTK7 antibodies

PROTEIN BROWSER
PTK7-001
PTK7-003
PTK7-004
PTK7-005
PTK7-006
PTK7-009
PTK7-012
PTK7-013
PTK7-015
PTK7-020

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PTK7-001
ENSP00000230419
ENST00000230419
Q13308 [Direct mapping]
Inactive tyrosine-protein kinase 7
Show all
Enzymes
   Kinases
   Tyr protein kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001736 [establishment of planar polarity]
GO:0003401 [axis elongation]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005887 [integral component of plasma membrane]
GO:0005911 [cell-cell junction]
GO:0005925 [focal adhesion]
GO:0006468 [protein phosphorylation]
GO:0007155 [cell adhesion]
GO:0007165 [signal transduction]
GO:0010976 [positive regulation of neuron projection development]
GO:0016477 [cell migration]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0031532 [actin cytoskeleton reorganization]
GO:0060070 [canonical Wnt signaling pathway]
GO:0071300 [cellular response to retinoic acid]
Show all
 1070 aa
118.4 kDa 		Yes 1
PTK7-003
ENSP00000419037
ENST00000471863
Q86X91 [Direct mapping]
Inactive tyrosine-protein kinase 7; PTK7 protein
Show all
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001736 [establishment of planar polarity]
GO:0003401 [axis elongation]
GO:0005515 [protein binding]
Show all
 459 aa
50.4 kDa 		Yes 0
PTK7-004
ENSP00000325462
ENST00000349241
Q13308 [Direct mapping]
Inactive tyrosine-protein kinase 7
Show all
Enzymes
   Kinases
   Tyr protein kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001736 [establishment of planar polarity]
GO:0003401 [axis elongation]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005887 [integral component of plasma membrane]
GO:0005911 [cell-cell junction]
GO:0005925 [focal adhesion]
GO:0006468 [protein phosphorylation]
GO:0007155 [cell adhesion]
GO:0007165 [signal transduction]
GO:0010976 [positive regulation of neuron projection development]
GO:0016477 [cell migration]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0031532 [actin cytoskeleton reorganization]
GO:0060070 [canonical Wnt signaling pathway]
GO:0071300 [cellular response to retinoic acid]
Show all
 940 aa
103.6 kDa 		Yes 1
PTK7-005
ENSP00000326029
ENST00000352931
Q13308 [Direct mapping]
Inactive tyrosine-protein kinase 7
Show all
Enzymes
   Kinases
   Tyr protein kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001736 [establishment of planar polarity]
GO:0003401 [axis elongation]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005887 [integral component of plasma membrane]
GO:0005911 [cell-cell junction]
GO:0005925 [focal adhesion]
GO:0006468 [protein phosphorylation]
GO:0007155 [cell adhesion]
GO:0007165 [signal transduction]
GO:0010976 [positive regulation of neuron projection development]
GO:0016477 [cell migration]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0031532 [actin cytoskeleton reorganization]
GO:0060070 [canonical Wnt signaling pathway]
GO:0071300 [cellular response to retinoic acid]
Show all
 1014 aa
112.3 kDa 		Yes 1
PTK7-006
ENSP00000325992
ENST00000345201
Q13308 [Direct mapping]
Inactive tyrosine-protein kinase 7
Show all
Enzymes
   Kinases
   Tyr protein kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001736 [establishment of planar polarity]
GO:0003401 [axis elongation]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005887 [integral component of plasma membrane]
GO:0005911 [cell-cell junction]
GO:0005925 [focal adhesion]
GO:0006468 [protein phosphorylation]
GO:0007155 [cell adhesion]
GO:0007165 [signal transduction]
GO:0010976 [positive regulation of neuron projection development]
GO:0016477 [cell migration]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0031532 [actin cytoskeleton reorganization]
GO:0060070 [canonical Wnt signaling pathway]
GO:0071300 [cellular response to retinoic acid]
Show all
 1030 aa
113.8 kDa 		Yes 1
PTK7-009
ENSP00000418754
ENST00000481273
Q13308 [Direct mapping]
Inactive tyrosine-protein kinase 7
Show all
Enzymes
   Kinases
   Tyr protein kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001736 [establishment of planar polarity]
GO:0001843 [neural tube closure]
GO:0003281 [ventricular septum development]
GO:0003401 [axis elongation]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005911 [cell-cell junction]
GO:0005925 [focal adhesion]
GO:0006468 [protein phosphorylation]
GO:0007155 [cell adhesion]
GO:0007165 [signal transduction]
GO:0007507 [heart development]
GO:0010976 [positive regulation of neuron projection development]
GO:0016020 [membrane]
GO:0016477 [cell migration]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0031532 [actin cytoskeleton reorganization]
GO:0042060 [wound healing]
GO:0045198 [establishment of epithelial cell apical/basal polarity]
GO:0060026 [convergent extension]
GO:0060070 [canonical Wnt signaling pathway]
GO:0060484 [lung-associated mesenchyme development]
GO:0060976 [coronary vasculature development]
GO:0071300 [cellular response to retinoic acid]
GO:0090103 [cochlea morphogenesis]
GO:0090179 [planar cell polarity pathway involved in neural tube closure]
Show all
 1078 aa
119.2 kDa 		No 1
PTK7-012
ENSP00000420765
ENST00000489707
H0Y8F1 [Direct mapping]
Inactive tyrosine-protein kinase 7
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001736 [establishment of planar polarity]
GO:0003401 [axis elongation]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
GO:0016021 [integral component of membrane]
GO:0018108 [peptidyl-tyrosine phosphorylation]
Show all
 365 aa
40.9 kDa 		No 0
PTK7-013
ENSP00000417607
ENST00000476760
C9J9E8 [Direct mapping]
Inactive tyrosine-protein kinase 7
Show all
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001736 [establishment of planar polarity]
GO:0003401 [axis elongation]
GO:0005515 [protein binding]
Show all
 139 aa
14.9 kDa 		Yes 0
PTK7-015
ENSP00000420165
ENST00000481946
H7C5L0 [Direct mapping]
Inactive tyrosine-protein kinase 7
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001736 [establishment of planar polarity]
GO:0003401 [axis elongation]
GO:0005515 [protein binding]
Show all
 269 aa
29.9 kDa 		No 0
PTK7-020
ENSP00000420186
ENST00000473339
C9JQR6 [Direct mapping]
Inactive tyrosine-protein kinase 7
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001736 [establishment of planar polarity]
GO:0003401 [axis elongation]
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
 257 aa
28.6 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.