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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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SRF
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    CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

SRF

Gene description

Serum response factor

Protein class

Predicted intracellular proteins
Transcription factors

Predicted localization

Intracellular

Number of transcripts

1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Reliability score

Supported based on 2 antibodies.
HPA001819 , CAB005416
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PROGNOSTIC SUMMARY

Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Lymphoma

STAINING SUMMARY

HPA001819
CAB005416

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

A majority of malignant tissues showed weak to moderate nuclear immunoreactivity. Stomach- and pancreatic cancers and most malignant gliomas and endometrial cancers were negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Malignant cells showed weak to moderate nuclear immunoreactivity. Additional cytoplasmic positivity was observed in a several cases.

GENE INFORMATION

Gene name

SRF (HGNC Symbol)

Synonyms

MCM1

Description

Serum response factor (HGNC Symbol)

Entrez gene summary

This gene encodes a ubiquitous nuclear protein that stimulates both cell proliferation and differentiation. It is a member of the MADS (MCM1, Agamous, Deficiens, and SRF) box superfamily of transcription factors. This protein binds to the serum response element (SRE) in the promoter region of target genes. This protein regulates the activity of many immediate-early genes, for example c-fos, and thereby participates in cell cycle regulation, apoptosis, cell growth, and cell differentiation. This gene is the downstream target of many pathways; for example, the mitogen-activated protein kinase pathway (MAPK) that acts through the ternary complex factors (TCFs). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014]

Chromosome

6

Cytoband

p21.1

Chromosome location (bp)

43171299 - 43181507

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000112658 (version 83.38)

Entrez gene

6722

UniProt

P11831 (UniProt - Evidence at protein level)

neXtProt

NX_P11831

Antibodypedia

SRF antibodies

PROTEIN BROWSER

SRF-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SRF-001
ENSP00000265354
ENST00000265354
P11831 [Direct mapping]
Serum response factor
A0A024RD16 [Target identity:100%; Query identity:100%]
Serum response factor (C-fos serum response element-binding transcription factor), isoform CRA_a
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   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Transcription factors
   alpha-Helices exposed by beta-structures
Protein evidence (Kim et al 2014)
Show all
GO:0000790 [nuclear chromatin]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0000983 [transcription factor activity, RNA polymerase II core promoter sequence-specific]
GO:0001076 [transcription factor activity, RNA polymerase II transcription factor binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding]
GO:0001569 [patterning of blood vessels]
GO:0001666 [response to hypoxia]
GO:0001701 [in utero embryonic development]
GO:0001707 [mesoderm formation]
GO:0001764 [neuron migration]
GO:0001829 [trophectodermal cell differentiation]
GO:0001947 [heart looping]
GO:0002011 [morphogenesis of an epithelial sheet]
GO:0002042 [cell migration involved in sprouting angiogenesis]
GO:0002521 [leukocyte differentiation]
GO:0003257 [positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003705 [transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007015 [actin filament organization]
GO:0007160 [cell-matrix adhesion]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007369 [gastrulation]
GO:0007507 [heart development]
GO:0007616 [long-term memory]
GO:0008134 [transcription factor binding]
GO:0008285 [negative regulation of cell proliferation]
GO:0008306 [associative learning]
GO:0009636 [response to toxic substance]
GO:0009725 [response to hormone]
GO:0010669 [epithelial structure maintenance]
GO:0010735 [positive regulation of transcription via serum response element binding]
GO:0010736 [serum response element binding]
GO:0016337 [single organismal cell-cell adhesion]
GO:0021766 [hippocampus development]
GO:0022028 [tangential migration from the subventricular zone to the olfactory bulb]
GO:0030036 [actin cytoskeleton organization]
GO:0030038 [contractile actin filament bundle assembly]
GO:0030155 [regulation of cell adhesion]
GO:0030168 [platelet activation]
GO:0030220 [platelet formation]
GO:0030336 [negative regulation of cell migration]
GO:0030878 [thyroid gland development]
GO:0031175 [neuron projection development]
GO:0031490 [chromatin DNA binding]
GO:0033561 [regulation of water loss via skin]
GO:0034097 [response to cytokine]
GO:0035855 [megakaryocyte development]
GO:0035912 [dorsal aorta morphogenesis]
GO:0042789 [mRNA transcription from RNA polymerase II promoter]
GO:0042803 [protein homodimerization activity]
GO:0042826 [histone deacetylase binding]
GO:0043149 [stress fiber assembly]
GO:0043565 [sequence-specific DNA binding]
GO:0043589 [skin morphogenesis]
GO:0045059 [positive thymic T cell selection]
GO:0045214 [sarcomere organization]
GO:0045597 [positive regulation of cell differentiation]
GO:0045773 [positive regulation of axon extension]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0045987 [positive regulation of smooth muscle contraction]
GO:0046016 [positive regulation of transcription by glucose]
GO:0046716 [muscle cell cellular homeostasis]
GO:0046983 [protein dimerization activity]
GO:0048538 [thymus development]
GO:0048589 [developmental growth]
GO:0048666 [neuron development]
GO:0048821 [erythrocyte development]
GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity]
GO:0051150 [regulation of smooth muscle cell differentiation]
GO:0051491 [positive regulation of filopodium assembly]
GO:0055003 [cardiac myofibril assembly]
GO:0060055 [angiogenesis involved in wound healing]
GO:0060218 [hematopoietic stem cell differentiation]
GO:0060261 [positive regulation of transcription initiation from RNA polymerase II promoter]
GO:0060292 [long term synaptic depression]
GO:0060324 [face development]
GO:0060347 [heart trabecula formation]
GO:0060425 [lung morphogenesis]
GO:0060532 [bronchus cartilage development]
GO:0060534 [trachea cartilage development]
GO:0060947 [cardiac vascular smooth muscle cell differentiation]
GO:0061029 [eyelid development in camera-type eye]
GO:0061145 [lung smooth muscle development]
GO:0070830 [bicellular tight junction assembly]
GO:0070878 [primary miRNA binding]
GO:0071333 [cellular response to glucose stimulus]
GO:0090009 [primitive streak formation]
GO:0090136 [epithelial cell-cell adhesion]
GO:0090398 [cellular senescence]
GO:1900222 [negative regulation of beta-amyloid clearance]
GO:1902894 [negative regulation of pri-miRNA transcription from RNA polymerase II promoter]
GO:1902895 [positive regulation of pri-miRNA transcription from RNA polymerase II promoter]
Show all
508 aa
51.6 kDa
No 0

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