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This gene encodes a ubiquitous nuclear protein that stimulates both cell proliferation and differentiation. It is a member of the MADS (MCM1, Agamous, Deficiens, and SRF) box superfamily of transcription factors. This protein binds to the serum response element (SRE) in the promoter region of target genes. This protein regulates the activity of many immediate-early genes, for example c-fos, and thereby participates in cell cycle regulation, apoptosis, cell growth, and cell differentiation. This gene is the downstream target of many pathways; for example, the mitogen-activated protein kinase pathway (MAPK) that acts through the ternary complex factors (TCFs). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014]
SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Transcription factors alpha-Helices exposed by beta-structures Protein evidence (Kim et al 2014)
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GO:0000790 [nuclear chromatin] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0000983 [transcription factor activity, RNA polymerase II core promoter sequence-specific] GO:0001076 [transcription factor activity, RNA polymerase II transcription factor binding] GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding] GO:0001569 [patterning of blood vessels] GO:0001666 [response to hypoxia] GO:0001701 [in utero embryonic development] GO:0001707 [mesoderm formation] GO:0001764 [neuron migration] GO:0001829 [trophectodermal cell differentiation] GO:0001947 [heart looping] GO:0002011 [morphogenesis of an epithelial sheet] GO:0002042 [cell migration involved in sprouting angiogenesis] GO:0002521 [leukocyte differentiation] GO:0003257 [positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003705 [transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0007015 [actin filament organization] GO:0007160 [cell-matrix adhesion] GO:0007264 [small GTPase mediated signal transduction] GO:0007369 [gastrulation] GO:0007507 [heart development] GO:0007616 [long-term memory] GO:0008134 [transcription factor binding] GO:0008285 [negative regulation of cell proliferation] GO:0008306 [associative learning] GO:0009636 [response to toxic substance] GO:0009725 [response to hormone] GO:0010669 [epithelial structure maintenance] GO:0010735 [positive regulation of transcription via serum response element binding] GO:0010736 [serum response element binding] GO:0016337 [single organismal cell-cell adhesion] GO:0021766 [hippocampus development] GO:0022028 [tangential migration from the subventricular zone to the olfactory bulb] GO:0030036 [actin cytoskeleton organization] GO:0030038 [contractile actin filament bundle assembly] GO:0030155 [regulation of cell adhesion] GO:0030168 [platelet activation] GO:0030220 [platelet formation] GO:0030336 [negative regulation of cell migration] GO:0030878 [thyroid gland development] GO:0031175 [neuron projection development] GO:0031490 [chromatin DNA binding] GO:0033561 [regulation of water loss via skin] GO:0034097 [response to cytokine] GO:0035855 [megakaryocyte development] GO:0035912 [dorsal aorta morphogenesis] GO:0042789 [mRNA transcription from RNA polymerase II promoter] GO:0042803 [protein homodimerization activity] GO:0042826 [histone deacetylase binding] GO:0043149 [stress fiber assembly] GO:0043565 [sequence-specific DNA binding] GO:0043589 [skin morphogenesis] GO:0045059 [positive thymic T cell selection] GO:0045214 [sarcomere organization] GO:0045597 [positive regulation of cell differentiation] GO:0045773 [positive regulation of axon extension] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0045987 [positive regulation of smooth muscle contraction] GO:0046016 [positive regulation of transcription by glucose] GO:0046716 [muscle cell cellular homeostasis] GO:0046983 [protein dimerization activity] GO:0048538 [thymus development] GO:0048589 [developmental growth] GO:0048666 [neuron development] GO:0048821 [erythrocyte development] GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity] GO:0051150 [regulation of smooth muscle cell differentiation] GO:0051491 [positive regulation of filopodium assembly] GO:0055003 [cardiac myofibril assembly] GO:0060055 [angiogenesis involved in wound healing] GO:0060218 [hematopoietic stem cell differentiation] GO:0060261 [positive regulation of transcription initiation from RNA polymerase II promoter] GO:0060292 [long term synaptic depression] GO:0060324 [face development] GO:0060347 [heart trabecula formation] GO:0060425 [lung morphogenesis] GO:0060532 [bronchus cartilage development] GO:0060534 [trachea cartilage development] GO:0060947 [cardiac vascular smooth muscle cell differentiation] GO:0061029 [eyelid development in camera-type eye] GO:0061145 [lung smooth muscle development] GO:0070830 [bicellular tight junction assembly] GO:0070878 [primary miRNA binding] GO:0071333 [cellular response to glucose stimulus] GO:0090009 [primitive streak formation] GO:0090136 [epithelial cell-cell adhesion] GO:0090398 [cellular senescence] GO:1900222 [negative regulation of beta-amyloid clearance] GO:1902894 [negative regulation of pri-miRNA transcription from RNA polymerase II promoter] GO:1902895 [positive regulation of pri-miRNA transcription from RNA polymerase II promoter]