Expression of SENP6 in cancer - Summary - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

SENP6

TISSUE

premium

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	SENP6
Gene description	SUMO1/sentrin specific peptidase 6
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General nuclear or nucleolar expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA024376
	SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in thyroid cancer (unfavourable) and renal cancer (unfavourable).
Thyroid cancer p<0.001 Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA024376

GENE INFORMATION
Gene name	SENP6 (HGNC Symbol)
Synonyms	KIAA0797, SUSP1
Description	SUMO1/sentrin specific peptidase 6 (HGNC Symbol)
Entrez gene summary	Ubiquitin-like molecules (UBLs), such as SUMO1 (UBL1; MIM 601912), are structurally related to ubiquitin (MIM 191339) and can be ligated to target proteins in a similar manner as ubiquitin. However, covalent attachment of UBLs does not result in degradation of the modified proteins. SUMO1 modification is implicated in the targeting of RANGAP1 (MIM 602362) to the nuclear pore complex, as well as in stabilization of I-kappa-B-alpha (NFKBIA; MIM 164008) from degradation by the 26S proteasome. Like ubiquitin, UBLs are synthesized as precursor proteins, with 1 or more amino acids following the C-terminal glycine-glycine residues of the mature UBL protein. Thus, the tail sequences of the UBL precursors need to be removed by UBL-specific proteases, such as SENP6, prior to their conjugation to target proteins (Kim et al., 2000 [PubMed 10799485]). SENPs also display isopeptidase activity for deconjugation of SUMO-conjugated substrates (Lima and Reverter, 2008 [PubMed 18799455]).[supplied by OMIM, Jun 2009]
Chromosome	6
Cytoband	q14.1
Chromosome location (bp)	75601509 - 75718278
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000112701 (version 83.38)
Entrez gene	26054
UniProt	Q9GZR1 (UniProt - Evidence at protein level)
neXtProt	NX_Q9GZR1
Antibodypedia	SENP6 antibodies

PROTEIN BROWSER

SENP6-002	SENP6-003	SENP6-004	SENP6-007	SENP6-010

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SENP6-002 ENSP00000359027 ENST00000370010	Q9GZR1 [Direct mapping] Sentrin-specific protease 6 Show all	Enzymes ENZYME proteins Hydrolases Peptidases Cysteine-type peptidases MEMSAT3 predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006508 [proteolysis] GO:0008234 [cysteine-type peptidase activity] GO:0016925 [protein sumoylation] GO:0016926 [protein desumoylation] GO:0016929 [SUMO-specific protease activity] GO:0070646 [protein modification by small protein removal] GO:0090169 [regulation of spindle assembly] GO:0090234 [regulation of kinetochore assembly] Show all	1105 aa 125.3 kDa	No	0
SENP6-003 ENSP00000426480 ENST00000483859	D6RG09 [Direct mapping] Sentrin-specific protease 6 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		220 aa 24.8 kDa	No	0
SENP6-004 ENSP00000402527 ENST00000447266	Q9GZR1 [Direct mapping] Sentrin-specific protease 6 Show all	Enzymes ENZYME proteins Hydrolases Peptidases Cysteine-type peptidases MEMSAT3 predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006508 [proteolysis] GO:0008234 [cysteine-type peptidase activity] GO:0016925 [protein sumoylation] GO:0016926 [protein desumoylation] GO:0016929 [SUMO-specific protease activity] GO:0070646 [protein modification by small protein removal] GO:0090169 [regulation of spindle assembly] GO:0090234 [regulation of kinetochore assembly] Show all	1112 aa 126.1 kDa	No	0
SENP6-007 ENSP00000391426 ENST00000424947	H0Y4F4 [Direct mapping] Sentrin-specific protease 6 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] Show all	582 aa 65.7 kDa	No	0
SENP6-010 ENSP00000321820 ENST00000327284	F8W6D9 [Direct mapping] Sentrin-specific protease 6 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] Show all	685 aa 76.9 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.