Tissue expression of IMPG1 - Summary - The Human Protein Atlas

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IMPG1

TISSUE

CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	IMPG1
Gene description	Interphotoreceptor matrix proteoglycan 1
Protein class	Disease related genes Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Mixed
GTEx:	Mixed
FANTOM5:	Tissue enriched (retina)

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in photoreceptor cells.

DATA RELIABILITY
Data reliability description	Presumed off target binding observed and disregarded. External characterization data supports antibody staining but no internal RNA data available for correlation.
Reliability score	Supported based on 3 antibodies. HPA027142 , HPA030332 , HPA030333
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Eye

N/A

Retina

N/A

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Mixed
GTEx dataset Organ Expression Alphabetical RNA tissue category: Mixed
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (retina)

GENE INFORMATION
Gene name	IMPG1 (HGNC Symbol)
Synonyms	GP147, IPM150, SPACR
Description	Interphotoreceptor matrix proteoglycan 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a protein that is a major component of the retinal interphotoreceptor matrix. The encoded protein is a proteoglycan that is thought to play a role in maintaining viability of photoreceptor cells and in adhesion of the neural retina to the retinal pigment epithelium. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Chromosome	6
Cytoband	q14.1
Chromosome location (bp)	75921115 - 76072678
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000112706 (version 83.38)
Entrez gene	3617
UniProt	Q17R60 (UniProt - Evidence at protein level)
neXtProt	NX_Q17R60
Antibodypedia	IMPG1 antibodies

PROTEIN BROWSER

IMPG1-001	IMPG1-002	IMPG1-201	IMPG1-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
IMPG1-001 ENSP00000358966 ENST00000369950	Q17R60 [Direct mapping] Interphotoreceptor matrix proteoglycan 1 Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005201 [extracellular matrix structural constituent] GO:0005515 [protein binding] GO:0005578 [proteinaceous extracellular matrix] GO:0007601 [visual perception] Show all	797 aa 89.4 kDa	Yes	0
IMPG1-002 ENSP00000358968 ENST00000369952	Q5JSC4 [Direct mapping] Interphotoreceptor matrix proteoglycan 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	158 aa 17.7 kDa	No	0
IMPG1-201 ENSP00000358980 ENST00000369963		SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		140 aa 16.5 kDa	No	0
IMPG1-202 ENSP00000481913 ENST00000611179	A0A087WYL3 [Direct mapping] Interphotoreceptor matrix proteoglycan 1 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	719 aa 80.1 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.