Cell atlas - PRPF4B - The Human Protein Atlas

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PRPF4B

TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nuclear speckles

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	PRPF4B
Gene description	Pre-mRNA processing factor 4B
Protein class	Enzymes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nuclear speckles.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nuclear speckles (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA020638
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nuclear speckles.

Main location

Nuclear speckles (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA020638	A-431	Nuclear speckles
	HPA020638	U-2 OS	Nuclear speckles
	HPA020638	U-251 MG	Nuclear speckles

GENE INFORMATION
Gene name	PRPF4B (HGNC Symbol)
Synonyms	KIAA0536, PR4H, Prp4
Description	Pre-mRNA processing factor 4B (HGNC Symbol)
Entrez gene summary	Pre-mRNA splicing occurs in two sequential transesterification steps, and the protein encoded by this gene is thought to be involved in pre-mRNA splicing and in signal transduction. This protein belongs to a kinase family that includes serine/arginine-rich protein-specific kinases and cyclin-dependent kinases (CDKs). This protein is regarded as a CDK-like kinase (Clk) with homology to mitogen-activated protein kinases (MAPKs). [provided by RefSeq, Jul 2008]
Chromosome	6
Cytoband	p25.2
Chromosome location (bp)	4021267 - 4064983
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000112739 (version 83.38)
Entrez gene	8899
UniProt	Q13523 (UniProt - Evidence at protein level)
neXtProt	NX_Q13523
Antibodypedia	PRPF4B antibodies

PROTEIN BROWSER

PRPF4B-011

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PRPF4B-011 ENSP00000337194 ENST00000337659	Q13523 [Direct mapping] Serine/threonine-protein kinase PRP4 homolog A0A024QZY5 [Target identity:100%; Query identity:100%] PRP4 pre-mRNA processing factor 4 homolog B (Yeast), isoform CRA_a Show all	Enzymes ENZYME proteins Transferases Kinases CMGC Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000398 [mRNA splicing, via spliceosome] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005654 [nucleoplasm] GO:0005694 [chromosome] GO:0006468 [protein phosphorylation] GO:0008380 [RNA splicing] GO:0044822 [poly(A) RNA binding] GO:0071013 [catalytic step 2 spliceosome] Show all	1007 aa 117 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.