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PRPF4B

GENERAL INFORMATION

Gene name

 PRPF4B

Gene description

 Pre-mRNA processing factor 4B

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Nuclear and cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA020638
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PROGNOSTIC SUMMARY
Prognostic marker in urothelial cancer (favourable) and liver cancer (unfavourable).
Urothelial cancer p<0.001
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA020638

GENE INFORMATION

Gene name

 PRPF4B (HGNC Symbol)

Synonyms

 KIAA0536, PR4H, Prp4

Description

 Pre-mRNA processing factor 4B (HGNC Symbol)

Entrez gene summary

 Pre-mRNA splicing occurs in two sequential transesterification steps, and the protein encoded by this gene is thought to be involved in pre-mRNA splicing and in signal transduction. This protein belongs to a kinase family that includes serine/arginine-rich protein-specific kinases and cyclin-dependent kinases (CDKs). This protein is regarded as a CDK-like kinase (Clk) with homology to mitogen-activated protein kinases (MAPKs). [provided by RefSeq, Jul 2008]

Chromosome

 6

Cytoband

 p25.2

Chromosome location (bp)

 4021267 - 4064983

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000112739 (version 83.38)

Entrez gene

 8899

UniProt

 Q13523 (UniProt - Evidence at protein level)

neXtProt

 NX_Q13523

Antibodypedia

 PRPF4B antibodies

PROTEIN BROWSER
PRPF4B-011

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PRPF4B-011
ENSP00000337194
ENST00000337659
Q13523 [Direct mapping]
Serine/threonine-protein kinase PRP4 homolog
A0A024QZY5 [Target identity:100%; Query identity:100%]
PRP4 pre-mRNA processing factor 4 homolog B (Yeast), isoform CRA_a
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CMGC Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000398 [mRNA splicing, via spliceosome]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005694 [chromosome]
GO:0006468 [protein phosphorylation]
GO:0008380 [RNA splicing]
GO:0044822 [poly(A) RNA binding]
GO:0071013 [catalytic step 2 spliceosome]
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 1007 aa
117 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.