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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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HMGCS1
  • TISSUE

  • premium

    CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

HMGCS1

Gene description

3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)

Protein class

Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and nuclear expression of varying intensity in selected tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

Approved based on 3 antibodies.
HPA036913 , HPA036914 , CAB032907
SHOW MORE

PROGNOSTIC SUMMARY

Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA036913
HPA036914
CAB032907

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Hepatocellular carcinomas and colorectal cancers along with several squamous cell carcinomas, urothelial, pancreatic, breast and gastric cancers showed moderate to strong cytoplasmic staining with additional nuclear or membranous immunoreactivity in a few cases. Remaining cancers were weakly stained or negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Most cancer tissues displayed moderate to strong cytoplasmic and nuclear immunoreactivity. Gliomas and melanomas as well as thyroid and renal cancers along with several cases of lymphomas were negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

A majority of cancer tissues showed weak to moderate cytoplasmic positivity. A few hepatocellular carcinomas were strongly stained. Gliomas, lymphomas, melanomas and skin cancers were generally negative.

GENE INFORMATION

Gene name

HMGCS1 (HGNC Symbol)

Synonyms

HMGCS

Description

3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) (HGNC Symbol)

Entrez gene summary

Chromosome

5

Cytoband

p12

Chromosome location (bp)

43289395 - 43313512

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000112972 (version 83.38)

Entrez gene

3157

UniProt

Q01581 (UniProt - Evidence at protein level)

neXtProt

NX_Q01581

Antibodypedia

HMGCS1 antibodies

PROTEIN BROWSER

HMGCS1-001
HMGCS1-003
HMGCS1-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

HMGCS1-001
ENSP00000322706
ENST00000325110
Q01581 [Direct mapping]
Hydroxymethylglutaryl-CoA synthase, cytoplasmic
A0A024R059 [Target identity:100%; Query identity:100%]
3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (Soluble), isoform CRA_a
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001889 [liver development]
GO:0003824 [catalytic activity]
GO:0004421 [hydroxymethylglutaryl-CoA synthase activity]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006629 [lipid metabolic process]
GO:0006695 [cholesterol biosynthetic process]
GO:0007420 [brain development]
GO:0008144 [drug binding]
GO:0008152 [metabolic process]
GO:0008299 [isoprenoid biosynthetic process]
GO:0008584 [male gonad development]
GO:0009645 [response to low light intensity stimulus]
GO:0009725 [response to hormone]
GO:0010033 [response to organic substance]
GO:0010243 [response to organonitrogen compound]
GO:0014070 [response to organic cyclic compound]
GO:0014074 [response to purine-containing compound]
GO:0016853 [isomerase activity]
GO:0033197 [response to vitamin E]
GO:0034698 [response to gonadotropin]
GO:0042493 [response to drug]
GO:0042803 [protein homodimerization activity]
GO:0043177 [organic acid binding]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0046690 [response to tellurium ion]
GO:0055094 [response to lipoprotein particle]
GO:0070723 [response to cholesterol]
GO:0071372 [cellular response to follicle-stimulating hormone stimulus]
GO:0071397 [cellular response to cholesterol]
GO:0071407 [cellular response to organic cyclic compound]
Show all
520 aa
57.3 kDa
No 0
HMGCS1-003
ENSP00000399402
ENST00000433297
Q01581 [Direct mapping]
Hydroxymethylglutaryl-CoA synthase, cytoplasmic
A0A024R059 [Target identity:100%; Query identity:100%]
3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (Soluble), isoform CRA_a
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0004421 [hydroxymethylglutaryl-CoA synthase activity]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006629 [lipid metabolic process]
GO:0006695 [cholesterol biosynthetic process]
GO:0008152 [metabolic process]
GO:0008299 [isoprenoid biosynthetic process]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
Show all
520 aa
57.3 kDa
No 0
HMGCS1-004
ENSP00000427339
ENST00000511774
D6RIW1 [Direct mapping]
Hydroxymethylglutaryl-CoA synthase, cytoplasmic
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0004421 [hydroxymethylglutaryl-CoA synthase activity]
GO:0008152 [metabolic process]
GO:0008299 [isoprenoid biosynthetic process]
Show all
96 aa
10.6 kDa
No 0

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