We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
Fields »
 

Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
ABOUT
HELP
BLOG
  • THE HUMAN PROTEOME
  • THE HUMAN TISSUES
  • THE HUMAN CELL
  • HUMAN PATHOLOGY
  • PROTEIN CLASSES
  • PROTEIN EVIDENCE
    • NEWS
    • BLOG
    • EVENTS
    • PRESS ROOM
    • LEARN
    • DICTIONARY
    • METHODS
    • CELL LINES
  • THE PROJECT
  • INTRODUCTION
  • ORGANIZATION
  • PUBLICATIONS
  • PUBLICATION DATA
  • ANTIBODY SUBMISSION
  • ANTIBODY AVAILABILITY
  • LINKS
  • CONTACT
  • TECHNICAL DATA
  • ANTIBODY VALIDATION
  • ASSAYS & ANNOTATION
  • DISCLAIMER
  • DOWNLOADABLE DATA
  • HELP & FAQ
  • LICENCE & CITATION
  • PRIVACY STATEMENT
  • RELEASE HISTORY
HMGCS1
  • TISSUE

  • premium

    CELL

  • PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

HMGCS1

Gene description

3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)

Protein class

Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic and nuclear expression of varying intensity in selected tissues.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

Approved based on 3 antibodies.
HPA036913 , HPA036914 , CAB032907
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

HMGCS1 (HGNC Symbol)

Synonyms

HMGCS

Description

3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) (HGNC Symbol)

Entrez gene summary

Chromosome

5

Cytoband

p12

Chromosome location (bp)

43289395 - 43313512

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000112972 (version 83.38)

Entrez gene

3157

UniProt

Q01581 (UniProt - Evidence at protein level)

neXtProt

NX_Q01581

Antibodypedia

HMGCS1 antibodies

PROTEIN BROWSER

HMGCS1-001
HMGCS1-003
HMGCS1-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

HMGCS1-001
ENSP00000322706
ENST00000325110
Q01581 [Direct mapping]
Hydroxymethylglutaryl-CoA synthase, cytoplasmic
A0A024R059 [Target identity:100%; Query identity:100%]
3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (Soluble), isoform CRA_a
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001889 [liver development]
GO:0003824 [catalytic activity]
GO:0004421 [hydroxymethylglutaryl-CoA synthase activity]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006629 [lipid metabolic process]
GO:0006695 [cholesterol biosynthetic process]
GO:0007420 [brain development]
GO:0008144 [drug binding]
GO:0008152 [metabolic process]
GO:0008299 [isoprenoid biosynthetic process]
GO:0008584 [male gonad development]
GO:0009645 [response to low light intensity stimulus]
GO:0009725 [response to hormone]
GO:0010033 [response to organic substance]
GO:0010243 [response to organonitrogen compound]
GO:0014070 [response to organic cyclic compound]
GO:0014074 [response to purine-containing compound]
GO:0016853 [isomerase activity]
GO:0033197 [response to vitamin E]
GO:0034698 [response to gonadotropin]
GO:0042493 [response to drug]
GO:0042803 [protein homodimerization activity]
GO:0043177 [organic acid binding]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0046690 [response to tellurium ion]
GO:0055094 [response to lipoprotein particle]
GO:0070723 [response to cholesterol]
GO:0071372 [cellular response to follicle-stimulating hormone stimulus]
GO:0071397 [cellular response to cholesterol]
GO:0071407 [cellular response to organic cyclic compound]
Show all
520 aa
57.3 kDa
No 0
HMGCS1-003
ENSP00000399402
ENST00000433297
Q01581 [Direct mapping]
Hydroxymethylglutaryl-CoA synthase, cytoplasmic
A0A024R059 [Target identity:100%; Query identity:100%]
3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (Soluble), isoform CRA_a
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0004421 [hydroxymethylglutaryl-CoA synthase activity]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006629 [lipid metabolic process]
GO:0006695 [cholesterol biosynthetic process]
GO:0008152 [metabolic process]
GO:0008299 [isoprenoid biosynthetic process]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
Show all
520 aa
57.3 kDa
No 0
HMGCS1-004
ENSP00000427339
ENST00000511774
D6RIW1 [Direct mapping]
Hydroxymethylglutaryl-CoA synthase, cytoplasmic
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0004421 [hydroxymethylglutaryl-CoA synthase activity]
GO:0008152 [metabolic process]
GO:0008299 [isoprenoid biosynthetic process]
Show all
96 aa
10.6 kDa
No 0

Contact

  • BLOG
  • PRESS ROOM
  • contact@proteinatlas.org

The Project

  • INTRODUCTION
  • ORGANIZATION
  • PUBLICATIONS
  • DOWNLOADABLE DATA

The Human Protein Atlas

  • ANTIBODY AVAILABILITY
  • LICENCE & CITATION
  • HELP & FAQ
The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.