Tissue expression of NNT - Summary - The Human Protein Atlas

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NNT

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TISSUE

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CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	NNT
Gene description	Nicotinamide nucleotide transhydrogenase
Protein class	Disease related genes Enzymes Plasma proteins Potential drug targets Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in most tissues.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA004829 , CAB004975
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	NNT
Synonyms
Description	Nicotinamide nucleotide transhydrogenase (HGNC Symbol)
Entrez gene summary	This gene encodes an integral protein of the inner mitochondrial membrane. The enzyme couples hydride transfer between NAD(H) and NADP(+) to proton translocation across the inner mitochondrial membrane. Under most physiological conditions, the enzyme uses energy from the mitochondrial proton gradient to produce high concentrations of NADPH. The resulting NADPH is used for biosynthesis and in free radical detoxification. Two alternatively spliced variants, encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008]
Chromosome	5
Cytoband	p12
Chromosome location (bp)	43602692 - 43707405
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000112992 (version 83.38)
Entrez gene	23530
UniProt	Q13423 (UniProt - Evidence at protein level)
neXtProt	NX_Q13423
Antibodypedia	NNT antibodies

PROTEIN BROWSER

NNT-001	NNT-002	NNT-004	NNT-006	NNT-007	NNT-010	NNT-012

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NNT-001 ENSP00000264663 ENST00000264663	Q13423 [Direct mapping] NAD(P) transhydrogenase, mitochondrial A0A024R0C3 [Target identity:100%; Query identity:100%] Nicotinamide nucleotide transhydrogenase, isoform CRA_a Show all	Enzymes ENZYME proteins Oxidoreductases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003957 [NAD(P)+ transhydrogenase (B-specific) activity] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0005746 [mitochondrial respiratory chain] GO:0006099 [tricarboxylic acid cycle] GO:0006740 [NADPH regeneration] GO:0008746 [NAD(P)+ transhydrogenase activity] GO:0008750 [NAD(P)+ transhydrogenase (AB-specific) activity] GO:0015992 [proton transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016491 [oxidoreductase activity] GO:0044237 [cellular metabolic process] GO:0044281 [small molecule metabolic process] GO:0045454 [cell redox homeostasis] GO:0050661 [NADP binding] GO:0051287 [NAD binding] GO:0055114 [oxidation-reduction process] GO:0072593 [reactive oxygen species metabolic process] GO:1902600 [hydrogen ion transmembrane transport] Show all	1086 aa 113.9 kDa	No	>9
NNT-002 ENSP00000343873 ENST00000344920	Q13423 [Direct mapping] NAD(P) transhydrogenase, mitochondrial A0A024R0C3 [Target identity:100%; Query identity:100%] Nicotinamide nucleotide transhydrogenase, isoform CRA_a Show all	Enzymes ENZYME proteins Oxidoreductases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003957 [NAD(P)+ transhydrogenase (B-specific) activity] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0005746 [mitochondrial respiratory chain] GO:0006099 [tricarboxylic acid cycle] GO:0006740 [NADPH regeneration] GO:0008746 [NAD(P)+ transhydrogenase activity] GO:0008750 [NAD(P)+ transhydrogenase (AB-specific) activity] GO:0015992 [proton transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016491 [oxidoreductase activity] GO:0044237 [cellular metabolic process] GO:0044281 [small molecule metabolic process] GO:0045454 [cell redox homeostasis] GO:0050661 [NADP binding] GO:0051287 [NAD binding] GO:0055114 [oxidation-reduction process] GO:0072593 [reactive oxygen species metabolic process] GO:1902600 [hydrogen ion transmembrane transport] Show all	1086 aa 113.9 kDa	No	>9
NNT-004 ENSP00000426343 ENST00000512996	E9PCX7 [Direct mapping] NAD(P) transhydrogenase, mitochondrial Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005743 [mitochondrial inner membrane] GO:0008746 [NAD(P)+ transhydrogenase activity] GO:0008750 [NAD(P)+ transhydrogenase (AB-specific) activity] GO:0015992 [proton transport] GO:0016021 [integral component of membrane] GO:0016491 [oxidoreductase activity] GO:0045454 [cell redox homeostasis] GO:0050661 [NADP binding] GO:0055114 [oxidation-reduction process] Show all	955 aa 99.7 kDa	No	>9
NNT-006 ENSP00000421886 ENST00000512422	D6RAI5 [Direct mapping] NAD(P) transhydrogenase, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005743 [mitochondrial inner membrane] GO:0008746 [NAD(P)+ transhydrogenase activity] GO:0015992 [proton transport] GO:0016491 [oxidoreductase activity] GO:0045454 [cell redox homeostasis] GO:0055114 [oxidation-reduction process] Show all	217 aa 23.5 kDa	No	0
NNT-007 ENSP00000425542 ENST00000515208	D6RCR6 [Direct mapping] NAD(P) transhydrogenase, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005743 [mitochondrial inner membrane] GO:0008746 [NAD(P)+ transhydrogenase activity] GO:0015992 [proton transport] GO:0045454 [cell redox homeostasis] GO:0055114 [oxidation-reduction process] Show all	58 aa 6.4 kDa	No	0
NNT-010 ENSP00000421674 ENST00000503651	H0Y8P5 [Direct mapping] NAD(P) transhydrogenase, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005743 [mitochondrial inner membrane] GO:0008746 [NAD(P)+ transhydrogenase activity] GO:0015992 [proton transport] GO:0045454 [cell redox homeostasis] GO:0055114 [oxidation-reduction process] Show all	57 aa 6.1 kDa	No	0
NNT-012 ENSP00000427670 ENST00000505678	D6RHU2 [Direct mapping] NAD(P) transhydrogenase, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005743 [mitochondrial inner membrane] GO:0008746 [NAD(P)+ transhydrogenase activity] GO:0015992 [proton transport] GO:0016491 [oxidoreductase activity] GO:0045454 [cell redox homeostasis] GO:0055114 [oxidation-reduction process] Show all	199 aa 21.5 kDa	No	0

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