Cell atlas - PFDN1 - The Human Protein Atlas

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PFDN1

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nucleoli
	Plasma membrane

Human cell
	Cytosol
	Nucleoli
	Plasma Membrane

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GENERAL INFORMATION
Gene name	PFDN1
Gene description	Prefoldin subunit 1
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the plasma membrane & cytosol. In addition localized to the nucleoli.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Plasma membrane (approved), Cytosol (approved)
Additional location	In addition localized to the Nucleoli (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA006499
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the plasma membrane & cytosol. In addition localized to the nucleoli.

Main location

Plasma membrane (approved), Cytosol (approved)

Additional location

Nucleoli (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA006499	A-431	Nucleoli
			Plasma membrane
			Cytosol
	HPA006499	U-2 OS	Plasma membrane
	HPA006499	U-2 OS	Cytosol
	HPA006499	U-251 MG	Plasma membrane
	HPA006499	U-251 MG	Cytosol

GENE INFORMATION
Gene name	PFDN1 (HGNC Symbol)
Synonyms	PFD1
Description	Prefoldin subunit 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the prefoldin beta subunit family. The encoded protein is one of six subunits of prefoldin, a molecular chaperone complex that binds and stabilizes newly synthesized polypeptides, thereby allowing them to fold correctly. The complex, consisting of two alpha and four beta subunits, forms a double beta barrel assembly with six protruding coiled-coils. [provided by RefSeq, Jul 2008]
Chromosome	5
Cytoband	q31.3
Chromosome location (bp)	140245039 - 140303121
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000113068 (version 83.38)
Entrez gene	5201
UniProt	O60925 (UniProt - Evidence at protein level)
neXtProt	NX_O60925
Antibodypedia	PFDN1 antibodies

PROTEIN BROWSER

PFDN1-001	PFDN1-003	PFDN1-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PFDN1-001 ENSP00000261813 ENST00000261813	O60925 [Direct mapping] Prefoldin subunit 1 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0006355 [regulation of transcription, DNA-templated] GO:0006457 [protein folding] GO:0007049 [cell cycle] GO:0016272 [prefoldin complex] GO:0044183 [protein binding involved in protein folding] GO:0044267 [cellular protein metabolic process] GO:0051082 [unfolded protein binding] GO:0051084 ['de novo' posttranslational protein folding] Show all	122 aa 14.2 kDa	No	0
PFDN1-003 ENSP00000426383 ENST00000510217	D6RGG5 [Direct mapping] Prefoldin subunit 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		35 aa 3.9 kDa	No	0
PFDN1-007 ENSP00000428707 ENST00000524074	E5RGS4 [Direct mapping] Prefoldin subunit 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0006457 [protein folding] GO:0016272 [prefoldin complex] GO:0051082 [unfolded protein binding] Show all	117 aa 13.5 kDa	No	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.