Expression of PFDN1 in cancer - Summary - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

PFDN1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	PFDN1
Gene description	Prefoldin subunit 1
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	3
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Mainly cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA006499
	SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA006499

GENE INFORMATION
Gene name	PFDN1 (HGNC Symbol)
Synonyms	PFD1
Description	Prefoldin subunit 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the prefoldin beta subunit family. The encoded protein is one of six subunits of prefoldin, a molecular chaperone complex that binds and stabilizes newly synthesized polypeptides, thereby allowing them to fold correctly. The complex, consisting of two alpha and four beta subunits, forms a double beta barrel assembly with six protruding coiled-coils. [provided by RefSeq, Jul 2008]
Chromosome	5
Cytoband	q31.3
Chromosome location (bp)	140245039 - 140303121
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000113068 (version 83.38)
Entrez gene	5201
UniProt	O60925 (UniProt - Evidence at protein level)
neXtProt	NX_O60925
Antibodypedia	PFDN1 antibodies

PROTEIN BROWSER

PFDN1-001	PFDN1-003	PFDN1-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PFDN1-001 ENSP00000261813 ENST00000261813	O60925 [Direct mapping] Prefoldin subunit 1 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0006355 [regulation of transcription, DNA-templated] GO:0006457 [protein folding] GO:0007049 [cell cycle] GO:0016272 [prefoldin complex] GO:0044183 [protein binding involved in protein folding] GO:0044267 [cellular protein metabolic process] GO:0051082 [unfolded protein binding] GO:0051084 ['de novo' posttranslational protein folding] Show all	122 aa 14.2 kDa	No	0
PFDN1-003 ENSP00000426383 ENST00000510217	D6RGG5 [Direct mapping] Prefoldin subunit 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		35 aa 3.9 kDa	No	0
PFDN1-007 ENSP00000428707 ENST00000524074	E5RGS4 [Direct mapping] Prefoldin subunit 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0006457 [protein folding] GO:0016272 [prefoldin complex] GO:0051082 [unfolded protein binding] Show all	117 aa 13.5 kDa	No	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.