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Gliomas and colorectal cancer along with a few cases of most cancer tissues displayed moderate to strong cytoplasmic positivity. Additional nuclear staining was observed in a few cases. Cancer cells in general were weakly stained or negative.
Most cancer tisseus displayed weak to moderate cytoplasmic positivity. Most colorectal cancers and a few cases of ovarian, cervical, gastric and pancreatic cancers showed strong immunoreactivity.
HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
H0Y8K6 [Direct mapping] 3-hydroxy-3-methylglutaryl-coenzyme A reductase
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SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014)
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GO:0004420 [hydroxymethylglutaryl-CoA reductase (NADPH) activity] GO:0005622 [intracellular] GO:0008299 [isoprenoid biosynthetic process] GO:0015936 [coenzyme A metabolic process] GO:0016616 [oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor] GO:0050662 [coenzyme binding] GO:0055114 [oxidation-reduction process]
H0Y8F6 [Direct mapping] 3-hydroxy-3-methylglutaryl-coenzyme A reductase
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Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014)
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GO:0004420 [hydroxymethylglutaryl-CoA reductase (NADPH) activity] GO:0005622 [intracellular] GO:0008299 [isoprenoid biosynthetic process] GO:0015936 [coenzyme A metabolic process] GO:0016616 [oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor] GO:0050662 [coenzyme binding] GO:0055114 [oxidation-reduction process]