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SLC27A6

GENERAL INFORMATION

Gene name

 SLC27A6

Gene description

 Solute carrier family 27 (fatty acid transporter), member 6

Protein class

 Predicted intracellular proteins
Predicted membrane proteins
Transporters

Predicted localization

 Intracellular,Membrane

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enriched (thyroid cancer)
HPA (cell line):Cell line enriched (BEWO)
HPA (normal tissue):Tissue enhanced (adrenal gland, fallopian tube)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Approved based on 1 antibody.
HPA008987
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enriched (thyroid cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA008987

GENE INFORMATION

Gene name

 SLC27A6 (HGNC Symbol)

Synonyms

 ACSVL2, FACVL2, FATP6, VLCS-H1

Description

 Solute carrier family 27 (fatty acid transporter), member 6 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the fatty acid transport protein family (FATP). FATPs are involved in the uptake of long-chain fatty acids and have unique expression patterns. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 5

Cytoband

 q23.3

Chromosome location (bp)

 128538013 - 129033642

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000113396 (version 83.38)

Entrez gene

 28965

UniProt

 Q9Y2P4 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q9Y2P4

Antibodypedia

 SLC27A6 antibodies

PROTEIN BROWSER
SLC27A6-001
SLC27A6-002
SLC27A6-003
SLC27A6-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SLC27A6-001
ENSP00000262462
ENST00000262462
Q9Y2P4 [Direct mapping]
Long-chain fatty acid transport protein 6
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Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
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GO:0000038 [very long-chain fatty acid metabolic process]
GO:0000166 [nucleotide binding]
GO:0001676 [long-chain fatty acid metabolic process]
GO:0003824 [catalytic activity]
GO:0004467 [long-chain fatty acid-CoA ligase activity]
GO:0005886 [plasma membrane]
GO:0008152 [metabolic process]
GO:0015909 [long-chain fatty acid transport]
GO:0016021 [integral component of membrane]
GO:0031957 [very long-chain fatty acid-CoA ligase activity]
GO:0042383 [sarcolemma]
GO:0055085 [transmembrane transport]
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 619 aa
70.1 kDa 		No 2
SLC27A6-002
ENSP00000421759
ENST00000508645
D6RAJ2 [Direct mapping]
Long-chain fatty acid transport protein 6
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   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001676 [long-chain fatty acid metabolic process]
GO:0003824 [catalytic activity]
GO:0004467 [long-chain fatty acid-CoA ligase activity]
GO:0008152 [metabolic process]
GO:0015908 [fatty acid transport]
GO:0016021 [integral component of membrane]
GO:0031957 [very long-chain fatty acid-CoA ligase activity]
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 162 aa
17.7 kDa 		No 0
SLC27A6-003
ENSP00000378684
ENST00000395266
Q9Y2P4 [Direct mapping]
Long-chain fatty acid transport protein 6
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Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000038 [very long-chain fatty acid metabolic process]
GO:0000166 [nucleotide binding]
GO:0001676 [long-chain fatty acid metabolic process]
GO:0003824 [catalytic activity]
GO:0004467 [long-chain fatty acid-CoA ligase activity]
GO:0005886 [plasma membrane]
GO:0008152 [metabolic process]
GO:0015909 [long-chain fatty acid transport]
GO:0016021 [integral component of membrane]
GO:0042383 [sarcolemma]
GO:0055085 [transmembrane transport]
Show all
 619 aa
70.1 kDa 		No 2
SLC27A6-004
ENSP00000421024
ENST00000506176
Q9Y2P4 [Direct mapping]
Long-chain fatty acid transport protein 6
Show all
Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000038 [very long-chain fatty acid metabolic process]
GO:0000166 [nucleotide binding]
GO:0001676 [long-chain fatty acid metabolic process]
GO:0003824 [catalytic activity]
GO:0004467 [long-chain fatty acid-CoA ligase activity]
GO:0005886 [plasma membrane]
GO:0008152 [metabolic process]
GO:0015909 [long-chain fatty acid transport]
GO:0016021 [integral component of membrane]
GO:0042383 [sarcolemma]
GO:0055085 [transmembrane transport]
Show all
 619 aa
70.1 kDa 		No 2

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.