Cell atlas - SEC24A - The Human Protein Atlas

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SEC24A

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoli fibrillar center
	Vesicles

Human cell
	Nucleoli
	Vesicles

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GENERAL INFORMATION
Gene name	SEC24A
Gene description	SEC24 homolog A, COPII coat complex component
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleoli (fibrillar center) & vesicles.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoli fibrillar center (approved), Vesicles (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA056825
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleoli (fibrillar center) & vesicles.

Main location

Nucleoli fibrillar center (approved), Vesicles (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA056825	A-431	Nucleoli fibrillar center
	HPA056825	A-431	Vesicles
	HPA056825	Hep G2	Nucleoli fibrillar center
	HPA056825	Hep G2	Vesicles
	HPA056825	U-2 OS	Nucleoli fibrillar center
	HPA056825	U-2 OS	Vesicles

GENE INFORMATION
Gene name	SEC24A
Synonyms
Description	SEC24 homolog A, COPII coat complex component (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene belongs to a family of proteins that are homologous to yeast Sec24. This protein is a component of coat protein II (COPII)-coated vesicles that mediate protein transport from the endoplasmic reticulum. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the golgi complex. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Chromosome	5
Cytoband	q31.1
Chromosome location (bp)	134648789 - 134727823
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000113615 (version 83.38)
Entrez gene	10802
UniProt	O95486 (UniProt - Evidence at protein level)
neXtProt	NX_O95486
Antibodypedia	SEC24A antibodies

PROTEIN BROWSER

SEC24A-001	SEC24A-002	SEC24A-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SEC24A-001 ENSP00000381823 ENST00000398844	O95486 [Direct mapping] Protein transport protein Sec24A Show all	Phobius predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I] GO:0003674 [molecular_function] GO:0005515 [protein binding] GO:0005789 [endoplasmic reticulum membrane] GO:0005829 [cytosol] GO:0006886 [intracellular protein transport] GO:0006888 [ER to Golgi vesicle-mediated transport] GO:0008270 [zinc ion binding] GO:0012507 [ER to Golgi transport vesicle membrane] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II] GO:0030127 [COPII vesicle coat] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0044281 [small molecule metabolic process] GO:0045714 [regulation of low-density lipoprotein particle receptor biosynthetic process] GO:0048208 [COPII vesicle coating] GO:0048471 [perinuclear region of cytoplasm] GO:0050714 [positive regulation of protein secretion] GO:0061024 [membrane organization] GO:2000189 [positive regulation of cholesterol homeostasis] Show all	1093 aa 119.7 kDa	No	0
SEC24A-002 ENSP00000321749 ENST00000322887	O95486 [Direct mapping] Protein transport protein Sec24A Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I] GO:0003674 [molecular_function] GO:0005515 [protein binding] GO:0005789 [endoplasmic reticulum membrane] GO:0005829 [cytosol] GO:0006886 [intracellular protein transport] GO:0006888 [ER to Golgi vesicle-mediated transport] GO:0008270 [zinc ion binding] GO:0012507 [ER to Golgi transport vesicle membrane] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II] GO:0030127 [COPII vesicle coat] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0044281 [small molecule metabolic process] GO:0048208 [COPII vesicle coating] GO:0048471 [perinuclear region of cytoplasm] GO:0061024 [membrane organization] Show all	613 aa 66 kDa	No	0
SEC24A-003 ENSP00000424273 ENST00000513123	H0Y9J6 [Direct mapping] Protein transport protein Sec24A Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006886 [intracellular protein transport] GO:0006888 [ER to Golgi vesicle-mediated transport] GO:0008270 [zinc ion binding] GO:0030127 [COPII vesicle coat] Show all	150 aa 17.3 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.