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SEC24A

GENERAL INFORMATION

Gene name

 SEC24A

Gene description

 SEC24 homolog A, COPII coat complex component

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA038901
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PROGNOSTIC SUMMARY
Prognostic marker in cervical cancer (unfavourable).
Cervical cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA038901

GENE INFORMATION

Gene name

 SEC24A

Synonyms

Description

 SEC24 homolog A, COPII coat complex component (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene belongs to a family of proteins that are homologous to yeast Sec24. This protein is a component of coat protein II (COPII)-coated vesicles that mediate protein transport from the endoplasmic reticulum. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the golgi complex. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

Chromosome

 5

Cytoband

 q31.1

Chromosome location (bp)

 134648789 - 134727823

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000113615 (version 83.38)

Entrez gene

 10802

UniProt

 O95486 (UniProt - Evidence at protein level)

neXtProt

 NX_O95486

Antibodypedia

 SEC24A antibodies

PROTEIN BROWSER
SEC24A-001
SEC24A-002
SEC24A-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SEC24A-001
ENSP00000381823
ENST00000398844
O95486 [Direct mapping]
Protein transport protein Sec24A
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   Phobius predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000139 [Golgi membrane]
GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I]
GO:0003674 [molecular_function]
GO:0005515 [protein binding]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005829 [cytosol]
GO:0006886 [intracellular protein transport]
GO:0006888 [ER to Golgi vesicle-mediated transport]
GO:0008270 [zinc ion binding]
GO:0012507 [ER to Golgi transport vesicle membrane]
GO:0018279 [protein N-linked glycosylation via asparagine]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
GO:0030127 [COPII vesicle coat]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045714 [regulation of low-density lipoprotein particle receptor biosynthetic process]
GO:0048208 [COPII vesicle coating]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050714 [positive regulation of protein secretion]
GO:0061024 [membrane organization]
GO:2000189 [positive regulation of cholesterol homeostasis]
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 1093 aa
119.7 kDa 		No 0
SEC24A-002
ENSP00000321749
ENST00000322887
O95486 [Direct mapping]
Protein transport protein Sec24A
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I]
GO:0003674 [molecular_function]
GO:0005515 [protein binding]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005829 [cytosol]
GO:0006886 [intracellular protein transport]
GO:0006888 [ER to Golgi vesicle-mediated transport]
GO:0008270 [zinc ion binding]
GO:0012507 [ER to Golgi transport vesicle membrane]
GO:0018279 [protein N-linked glycosylation via asparagine]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
GO:0030127 [COPII vesicle coat]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0048208 [COPII vesicle coating]
GO:0048471 [perinuclear region of cytoplasm]
GO:0061024 [membrane organization]
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 613 aa
66 kDa 		No 0
SEC24A-003
ENSP00000424273
ENST00000513123
H0Y9J6 [Direct mapping]
Protein transport protein Sec24A
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006886 [intracellular protein transport]
GO:0006888 [ER to Golgi vesicle-mediated transport]
GO:0008270 [zinc ion binding]
GO:0030127 [COPII vesicle coat]
Show all
 150 aa
17.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.