Tissue expression of BCHE - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	BCHE
Gene description	Butyrylcholinesterase
Protein class	Disease related genes Enzymes FDA approved drug targets Plasma proteins Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (liver)
GTEx:	Tissue enhanced (fallopian tube)
FANTOM5:	Mixed

Protein evidence

Evidence at protein level

Protein expression

Secrete and plasma positivity in several tissues.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 1 antibody. HPA001560
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (liver)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (fallopian tube)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Mixed

GENE INFORMATION
Gene name	BCHE (HGNC Symbol)
Synonyms	CHE1, CHE2, E1
Description	Butyrylcholinesterase (HGNC Symbol)
Entrez gene summary	Mutant alleles at the BCHE locus are responsible for suxamethonium sensitivity. Homozygous persons sustain prolonged apnea after administration of the muscle relaxant suxamethonium in connection with surgical anesthesia. The activity of pseudocholinesterase in the serum is low and its substrate behavior is atypical. In the absence of the relaxant, the homozygote is at no known disadvantage. [provided by RefSeq, Jul 2008]
Chromosome	3
Cytoband	q26.1
Chromosome location (bp)	165772904 - 165837472
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000114200 (version 83.38)
Entrez gene	590
UniProt	P06276 (UniProt - Evidence at protein level)
neXtProt	NX_P06276
Antibodypedia	BCHE antibodies

PROTEIN BROWSER

BCHE-001	BCHE-002	BCHE-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
BCHE-001 ENSP00000264381 ENST00000264381	P06276 [Direct mapping] Cholinesterase Show all	Enzymes ENZYME proteins Hydrolases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001540 [beta-amyloid binding] GO:0003824 [catalytic activity] GO:0003990 [acetylcholinesterase activity] GO:0004104 [cholinesterase activity] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005641 [nuclear envelope lumen] GO:0005783 [endoplasmic reticulum] GO:0005788 [endoplasmic reticulum lumen] GO:0006581 [acetylcholine catabolic process] GO:0007268 [synaptic transmission] GO:0007584 [response to nutrient] GO:0007612 [learning] GO:0008285 [negative regulation of cell proliferation] GO:0014016 [neuroblast differentiation] GO:0016020 [membrane] GO:0019695 [choline metabolic process] GO:0019899 [enzyme binding] GO:0033265 [choline binding] GO:0042493 [response to drug] GO:0042802 [identical protein binding] GO:0043279 [response to alkaloid] GO:0044267 [cellular protein metabolic process] GO:0050783 [cocaine metabolic process] GO:0050805 [negative regulation of synaptic transmission] GO:0051384 [response to glucocorticoid] GO:0051593 [response to folic acid] GO:0072562 [blood microparticle] Show all	602 aa 68.4 kDa	Yes	0
BCHE-002 ENSP00000418325 ENST00000479451	H0Y885 [Direct mapping] Cholinesterase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		132 aa 15.6 kDa	No	0
BCHE-005 ENSP00000418504 ENST00000488954	H7C4Y0 [Direct mapping] Cholinesterase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		120 aa 13.6 kDa	No	0