Cell atlas - ACAP2 - The Human Protein Atlas

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ACAP2

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS CUSTOM DATA

GENE/PROTEIN

Antibody validation

Dictionary
	Endosomes

Human cell
	Vesicles

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GENERAL INFORMATION
Gene name	ACAP2
Gene description	ArfGAP with coiled-coil, ankyrin repeat and PH domains 2
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the endosome.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Endosomes (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA034808
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ASSAYS

RNA expression

Human cells

Custom data

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the endosome.

Main location

Endosomes (approved)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA034808	A-431	Endosomes
HPA034808	U-2 OS	Endosomes
HPA034808	U-251 MG	Endosomes

CUSTOM DATA


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Thumbnail	Antibody	Cell line	Assay	Description
	HPA034808	U-2 OS	Image	ACAP2 localizes to a subcompartment of endosomes, as it does not completely co-localize with the endosomal marker EEA1 on an endosome.


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Thumbnail	Antibody	Cell line	Assay	Description
	HPA034808	U-2 OS	Image	ACAP2 localizes to retromers, as it partially co-localizes with the retromer marker VPS26A.

GENE INFORMATION
Gene name	ACAP2 (HGNC Symbol)
Synonyms	CENTB2, CNT-B2, KIAA0041
Description	ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 (HGNC Symbol)
Entrez gene summary
Chromosome	3
Cytoband	q29
Chromosome location (bp)	195274736 - 195443078
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000114331 (version 83.38)
Entrez gene	23527
UniProt	Q15057 (UniProt - Evidence at protein level)
neXtProt	NX_Q15057
Antibodypedia	ACAP2 antibodies

PROTEIN BROWSER

ACAP2-001	ACAP2-005	ACAP2-007	ACAP2-010	ACAP2-015	ACAP2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ACAP2-001 ENSP00000324287 ENST00000326793	Q15057 [Direct mapping] Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005096 [GTPase activator activity] GO:0005515 [protein binding] GO:0010008 [endosome membrane] GO:0016020 [membrane] GO:0017137 [Rab GTPase binding] GO:0036010 [protein localization to endosome] GO:0043547 [positive regulation of GTPase activity] GO:0046872 [metal ion binding] GO:1990090 [cellular response to nerve growth factor stimulus] Show all	778 aa 88 kDa	No	0
ACAP2-005 ENSP00000411336 ENST00000439666	C9J8L1 [Direct mapping] Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		51 aa 5.7 kDa	No	0
ACAP2-007 ENSP00000413388 ENST00000439758	H7C3Q8 [Direct mapping] Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		256 aa 29.6 kDa	No	0
ACAP2-010 ENSP00000412338 ENST00000450200	H7C3K3 [Direct mapping] Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005096 [GTPase activator activity] GO:0043547 [positive regulation of GTPase activity] Show all	229 aa 25.7 kDa	No	0
ACAP2-015 ENSP00000489156 ENST00000635383		Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005096 [GTPase activator activity] Show all	547 aa 62.8 kDa	No	0
ACAP2-201 ENSP00000484209 ENST00000618471	A0A087X1H5 [Direct mapping] Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005096 [GTPase activator activity] GO:0005515 [protein binding] GO:0043547 [positive regulation of GTPase activity] Show all	777 aa 88 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.