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ACAP2

GENERAL INFORMATION

Gene name

 ACAP2

Gene description

 ArfGAP with coiled-coil, ankyrin repeat and PH domains 2

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA034807 , HPA034808
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA034807
HPA034808

GENE INFORMATION

Gene name

 ACAP2 (HGNC Symbol)

Synonyms

 CENTB2, CNT-B2, KIAA0041

Description

 ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 (HGNC Symbol)

Entrez gene summary

Chromosome

 3

Cytoband

 q29

Chromosome location (bp)

 195274736 - 195443078

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000114331 (version 83.38)

Entrez gene

 23527

UniProt

 Q15057 (UniProt - Evidence at protein level)

neXtProt

 NX_Q15057

Antibodypedia

 ACAP2 antibodies

PROTEIN BROWSER
ACAP2-001
ACAP2-005
ACAP2-007
ACAP2-010
ACAP2-015
ACAP2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ACAP2-001
ENSP00000324287
ENST00000326793
Q15057 [Direct mapping]
Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0010008 [endosome membrane]
GO:0016020 [membrane]
GO:0017137 [Rab GTPase binding]
GO:0036010 [protein localization to endosome]
GO:0043547 [positive regulation of GTPase activity]
GO:0046872 [metal ion binding]
GO:1990090 [cellular response to nerve growth factor stimulus]
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 778 aa
88 kDa 		No 0
ACAP2-005
ENSP00000411336
ENST00000439666
C9J8L1 [Direct mapping]
Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 51 aa
5.7 kDa 		No 0
ACAP2-007
ENSP00000413388
ENST00000439758
H7C3Q8 [Direct mapping]
Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 256 aa
29.6 kDa 		No 0
ACAP2-010
ENSP00000412338
ENST00000450200
H7C3K3 [Direct mapping]
Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005096 [GTPase activator activity]
GO:0043547 [positive regulation of GTPase activity]
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 229 aa
25.7 kDa 		No 0
ACAP2-015
ENSP00000489156
ENST00000635383
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005096 [GTPase activator activity]
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 547 aa
62.8 kDa 		No 0
ACAP2-201
ENSP00000484209
ENST00000618471
A0A087X1H5 [Direct mapping]
Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0043547 [positive regulation of GTPase activity]
Show all
 777 aa
88 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.