Tissue expression of CBLB - Summary - The Human Protein Atlas

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CBLB

TISSUE

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CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	CBLB
Gene description	Cbl proto-oncogene B, E3 ubiquitin protein ligase
Protein class	Cancer-related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in most tissues.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 2 antibodies. HPA018327 , HPA019880
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

N/A

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	CBLB (HGNC Symbol)
Synonyms	Cbl-b, RNF56
Description	Cbl proto-oncogene B, E3 ubiquitin protein ligase (HGNC Symbol)
Entrez gene summary
Chromosome	3
Cytoband	q13.11
Chromosome location (bp)	105655461 - 105869552
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000114423 (version 83.38)
Entrez gene	868
UniProt	Q13191 (UniProt - Evidence at protein level)
neXtProt	NX_Q13191
Antibodypedia	CBLB antibodies

PROTEIN BROWSER

CBLB-001	CBLB-002	CBLB-003	CBLB-005	CBLB-007	CBLB-008	CBLB-009	CBLB-010

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CBLB-001 ENSP00000264122 ENST00000264122	Q13191 [Direct mapping] E3 ubiquitin-protein ligase CBL-B Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Missense Mutations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001784 [phosphotyrosine binding] GO:0002669 [positive regulation of T cell anergy] GO:0004842 [ubiquitin-protein transferase activity] GO:0004871 [signal transducer activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006607 [NLS-bearing protein import into nucleus] GO:0006955 [immune response] GO:0007165 [signal transduction] GO:0007166 [cell surface receptor signaling pathway] GO:0008270 [zinc ion binding] GO:0009629 [response to gravity] GO:0009725 [response to hormone] GO:0016567 [protein ubiquitination] GO:0016874 [ligase activity] GO:0019901 [protein kinase binding] GO:0035556 [intracellular signal transduction] GO:0042110 [T cell activation] GO:0045121 [membrane raft] GO:0045732 [positive regulation of protein catabolic process] GO:0046642 [negative regulation of alpha-beta T cell proliferation] GO:0050860 [negative regulation of T cell receptor signaling pathway] Show all	982 aa 109.4 kDa	No	0
CBLB-002 ENSP00000384816 ENST00000403724	Q13191 [Direct mapping] E3 ubiquitin-protein ligase CBL-B Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Missense Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0001784 [phosphotyrosine binding] GO:0004842 [ubiquitin-protein transferase activity] GO:0004871 [signal transducer activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006607 [NLS-bearing protein import into nucleus] GO:0007165 [signal transduction] GO:0007166 [cell surface receptor signaling pathway] GO:0008270 [zinc ion binding] GO:0016567 [protein ubiquitination] GO:0016874 [ligase activity] Show all	770 aa 86.6 kDa	No	0
CBLB-003 ENSP00000384938 ENST00000405772	B5MC15 [Direct mapping] Cas-Br-M (Murine) ecotropic retroviral transforming sequence b, isoform CRA_a; E3 ubiquitin-protein ligase CBL-B Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Missense Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0001784 [phosphotyrosine binding] GO:0004842 [ubiquitin-protein transferase activity] GO:0004871 [signal transducer activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0007166 [cell surface receptor signaling pathway] GO:0008270 [zinc ion binding] GO:0016567 [protein ubiquitination] GO:0023051 [regulation of signaling] Show all	810 aa 90.8 kDa	No	0
CBLB-005 ENSP00000384170 ENST00000407712	E9PHA9 [Direct mapping] E3 ubiquitin-protein ligase CBL-B Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Missense Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0016567 [protein ubiquitination] GO:0023051 [regulation of signaling] Show all	197 aa 21.4 kDa	No	0
CBLB-007 ENSP00000377598 ENST00000394030	Q68CY2 [Direct mapping] E3 ubiquitin-protein ligase CBL-B; Putative uncharacterized protein DKFZp779A0729 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Missense Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0016567 [protein ubiquitination] GO:0023051 [regulation of signaling] Show all	321 aa 34.9 kDa	No	0
CBLB-008 ENSP00000393906 ENST00000443752	C9JU85 [Direct mapping] E3 ubiquitin-protein ligase CBL-B Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Missense Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0001784 [phosphotyrosine binding] GO:0004842 [ubiquitin-protein transferase activity] GO:0004871 [signal transducer activity] GO:0005634 [nucleus] GO:0007166 [cell surface receptor signaling pathway] GO:0016567 [protein ubiquitination] GO:0023051 [regulation of signaling] Show all	139 aa 16 kDa	No	0
CBLB-009 ENSP00000409750 ENST00000438603	C9JRB3 [Direct mapping] E3 ubiquitin-protein ligase CBL-B Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Missense Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0001784 [phosphotyrosine binding] GO:0004842 [ubiquitin-protein transferase activity] GO:0004871 [signal transducer activity] GO:0005634 [nucleus] GO:0007166 [cell surface receptor signaling pathway] GO:0016567 [protein ubiquitination] GO:0023051 [regulation of signaling] Show all	161 aa 18.4 kDa	No	0
CBLB-010 ENSP00000400949 ENST00000447441	C9JU85 [Direct mapping] E3 ubiquitin-protein ligase CBL-B Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Missense Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0001784 [phosphotyrosine binding] GO:0004842 [ubiquitin-protein transferase activity] GO:0004871 [signal transducer activity] GO:0005634 [nucleus] GO:0007166 [cell surface receptor signaling pathway] GO:0016567 [protein ubiquitination] GO:0023051 [regulation of signaling] Show all	139 aa 16 kDa	No	0

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The Human Protein Atlas project is funded
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