Expression of ROPN1B in cancer - Summary - The Human Protein Atlas

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ROPN1B

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ROPN1B
Gene description	Rhophilin associated tail protein 1B
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (melanoma)
HPA (cell line):	Group enriched (SK-MEL-30, WM-115)
HPA (normal tissue):	Tissue enriched (testis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in testis.

ANTIBODY IHC RELIABILITY
Data reliability description	Caution, targets protein from more than one gene. Presumed off target binding observed and disregarded. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA052530
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (melanoma)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA052530

GENE INFORMATION
Gene name	ROPN1B
Synonyms
Description	Rhophilin associated tail protein 1B (HGNC Symbol)
Entrez gene summary
Chromosome	3
Cytoband	q21.2
Chromosome location (bp)	125969144 - 125983454
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000114547 (version 83.38)
Entrez gene	152015
UniProt	Q9BZX4 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BZX4
Antibodypedia	ROPN1B antibodies

PROTEIN BROWSER

ROPN1B-001	ROPN1B-002	ROPN1B-003	ROPN1B-006	ROPN1B-007	ROPN1B-010	ROPN1B-011

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ROPN1B-001 ENSP00000251776 ENST00000251776	Q9BZX4 [Direct mapping] Ropporin-1B Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0000910 [cytokinesis] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0007266 [Rho protein signal transduction] GO:0007283 [spermatogenesis] GO:0007340 [acrosome reaction] GO:0007342 [fusion of sperm to egg plasma membrane] GO:0016337 [single organismal cell-cell adhesion] GO:0030159 [receptor signaling complex scaffold activity] GO:0030317 [sperm motility] GO:0031514 [motile cilium] GO:0042803 [protein homodimerization activity] GO:0046982 [protein heterodimerization activity] Show all	212 aa 24 kDa	No	0
ROPN1B-002 ENSP00000424457 ENST00000504401	D6RAA3 [Direct mapping] Ropporin-1B Show all	Predicted intracellular proteins Show all		58 aa 6.6 kDa	No	0
ROPN1B-003 ENSP00000426271 ENST00000514116	Q9BZX4 [Direct mapping] Ropporin-1B Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Show all	GO:0000910 [cytokinesis] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0007266 [Rho protein signal transduction] GO:0007283 [spermatogenesis] GO:0007340 [acrosome reaction] GO:0007342 [fusion of sperm to egg plasma membrane] GO:0016337 [single organismal cell-cell adhesion] GO:0030159 [receptor signaling complex scaffold activity] GO:0030317 [sperm motility] GO:0031514 [motile cilium] GO:0042803 [protein homodimerization activity] GO:0046982 [protein heterodimerization activity] Show all	212 aa 24 kDa	No	0
ROPN1B-006 ENSP00000424447 ENST00000511082	Q9BZX4 [Direct mapping] Ropporin-1B Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Show all	GO:0000910 [cytokinesis] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0007266 [Rho protein signal transduction] GO:0007283 [spermatogenesis] GO:0007340 [acrosome reaction] GO:0007342 [fusion of sperm to egg plasma membrane] GO:0016337 [single organismal cell-cell adhesion] GO:0030159 [receptor signaling complex scaffold activity] GO:0030317 [sperm motility] GO:0031514 [motile cilium] GO:0042803 [protein homodimerization activity] GO:0046982 [protein heterodimerization activity] Show all	120 aa 13.6 kDa	No	0
ROPN1B-007 ENSP00000425548 ENST00000513830	D6RCR2 [Direct mapping] Ropporin-1B Show all	Predicted intracellular proteins Show all		130 aa 14.8 kDa	No	0
ROPN1B-010 ENSP00000423058 ENST00000508088	D6RA85 [Direct mapping] Ropporin-1B Show all	Predicted intracellular proteins Show all		103 aa 11.7 kDa	No	0
ROPN1B-011 ENSP00000421662 ENST00000505382	Q9BZX4 [Direct mapping] Ropporin-1B Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Show all	GO:0000910 [cytokinesis] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0007266 [Rho protein signal transduction] GO:0007283 [spermatogenesis] GO:0007340 [acrosome reaction] GO:0007342 [fusion of sperm to egg plasma membrane] GO:0016337 [single organismal cell-cell adhesion] GO:0030159 [receptor signaling complex scaffold activity] GO:0030317 [sperm motility] GO:0031514 [motile cilium] GO:0042803 [protein homodimerization activity] GO:0046982 [protein heterodimerization activity] Show all	120 aa 13.6 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.