Expression of ABTB1 in cancer - Summary - The Human Protein Atlas

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ABTB1

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ABTB1
Gene description	Ankyrin repeat and BTB (POZ) domain containing 1
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Uncertain based on 2 antibodies. HPA035022 , HPA035023
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

Urothelial cancer

STAINING SUMMARY

HPA035022	HPA035023

GENE INFORMATION
Gene name	ABTB1 (HGNC Symbol)
Synonyms	BPOZ, Btb3, BTBD21, EF1ABP
Description	Ankyrin repeat and BTB (POZ) domain containing 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a protein with an ankyrin repeat region and two BTB/POZ domains, which are thought to be involved in protein-protein interactions. Expression of this gene is activated by the phosphatase and tensin homolog, a tumor suppressor. Alternate splicing results in three transcript variants. [provided by RefSeq, Mar 2010]
Chromosome	3
Cytoband	q21.3
Chromosome location (bp)	127672935 - 127680920
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000114626 (version 83.38)
Entrez gene	80325
UniProt	Q969K4 (UniProt - Evidence at protein level)
neXtProt	NX_Q969K4
Antibodypedia	ABTB1 antibodies

PROTEIN BROWSER

ABTB1-001	ABTB1-004	ABTB1-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ABTB1-001 ENSP00000232744 ENST00000232744	Q969K4 [Direct mapping] Ankyrin repeat and BTB/POZ domain-containing protein 1 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003746 [translation elongation factor activity] GO:0005515 [protein binding] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0006414 [translational elongation] Show all	478 aa 54 kDa	No	0
ABTB1-004 ENSP00000412684 ENST00000453791	Q969K4 [Direct mapping] Ankyrin repeat and BTB/POZ domain-containing protein 1 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003746 [translation elongation factor activity] GO:0005515 [protein binding] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0006414 [translational elongation] Show all	336 aa 37.6 kDa	No	0
ABTB1-006 ENSP00000417366 ENST00000468137	Q969K4 [Direct mapping] Ankyrin repeat and BTB/POZ domain-containing protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003746 [translation elongation factor activity] GO:0005515 [protein binding] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0006414 [translational elongation] Show all	336 aa 37.6 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.