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ABTB1

GENERAL INFORMATION

Gene name

 ABTB1

Gene description

 Ankyrin repeat and BTB (POZ) domain containing 1

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Uncertain based on 2 antibodies.
HPA035022 , HPA035023
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 ABTB1 (HGNC Symbol)

Synonyms

 BPOZ, Btb3, BTBD21, EF1ABP

Description

 Ankyrin repeat and BTB (POZ) domain containing 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein with an ankyrin repeat region and two BTB/POZ domains, which are thought to be involved in protein-protein interactions. Expression of this gene is activated by the phosphatase and tensin homolog, a tumor suppressor. Alternate splicing results in three transcript variants. [provided by RefSeq, Mar 2010]

Chromosome

 3

Cytoband

 q21.3

Chromosome location (bp)

 127672935 - 127680920

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000114626 (version 83.38)

Entrez gene

 80325

UniProt

 Q969K4 (UniProt - Evidence at protein level)

neXtProt

 NX_Q969K4

Antibodypedia

 ABTB1 antibodies

PROTEIN BROWSER
ABTB1-001
ABTB1-004
ABTB1-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ABTB1-001
ENSP00000232744
ENST00000232744
Q969K4 [Direct mapping]
Ankyrin repeat and BTB/POZ domain-containing protein 1
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003746 [translation elongation factor activity]
GO:0005515 [protein binding]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006414 [translational elongation]
Show all
 478 aa
54 kDa 		No 0
ABTB1-004
ENSP00000412684
ENST00000453791
Q969K4 [Direct mapping]
Ankyrin repeat and BTB/POZ domain-containing protein 1
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003746 [translation elongation factor activity]
GO:0005515 [protein binding]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006414 [translational elongation]
Show all
 336 aa
37.6 kDa 		No 0
ABTB1-006
ENSP00000417366
ENST00000468137
Q969K4 [Direct mapping]
Ankyrin repeat and BTB/POZ domain-containing protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003746 [translation elongation factor activity]
GO:0005515 [protein binding]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006414 [translational elongation]
Show all
 336 aa
37.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.