Expression of NEK11 in cancer - Summary - The Human Protein Atlas

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NEK11

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	NEK11
Gene description	NIMA-related kinase 11
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Mixed
HPA (normal tissue):	Tissue enhanced (fallopian tube)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Nuclear expression in several tissues, most abundant in testis.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. External characterization data supports antibody staining.
Reliability score	Approved based on 1 antibody. HPA016908
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and cervical cancer (favourable).
Renal cancer p<0.001 Cervical cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA016908

GENE INFORMATION
Gene name	NEK11 (HGNC Symbol)
Synonyms	FLJ23495
Description	NIMA-related kinase 11 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the never in mitosis gene A family of kinases. The encoded protein localizes to the nucleoli, and may function with NEK2A in the S-phase checkpoint. The encoded protein appears to play roles in DNA replication and response to genotoxic stress. Alternatively spliced transcript variants have been described.[provided by RefSeq, Mar 2009]
Chromosome	3
Cytoband	q22.1
Chromosome location (bp)	131026850 - 131350465
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000114670 (version 83.38)
Entrez gene	79858
UniProt	Q8NG66 (UniProt - Evidence at protein level)
neXtProt	NX_Q8NG66
Antibodypedia	NEK11 antibodies

PROTEIN BROWSER

NEK11-001	NEK11-003	NEK11-004	NEK11-005	NEK11-006	NEK11-010	NEK11-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NEK11-001 ENSP00000426662 ENST00000507910	Q8NG66 [Direct mapping] Serine/threonine-protein kinase Nek11 Show all	Enzymes ENZYME proteins Transferases Kinases NEK Ser/Thr protein kinases SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0006468 [protein phosphorylation] GO:0016572 [histone phosphorylation] GO:0031572 [G2 DNA damage checkpoint] GO:0031573 [intra-S DNA damage checkpoint] GO:0035556 [intracellular signal transduction] GO:0044772 [mitotic cell cycle phase transition] GO:0046872 [metal ion binding] GO:1901990 [regulation of mitotic cell cycle phase transition] Show all	482 aa 55.5 kDa	No	0
NEK11-003 ENSP00000372857 ENST00000383366	Q8NG66 [Direct mapping] Serine/threonine-protein kinase Nek11 Show all	Enzymes ENZYME proteins Transferases Kinases NEK Ser/Thr protein kinases THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0006468 [protein phosphorylation] GO:0016572 [histone phosphorylation] GO:0031572 [G2 DNA damage checkpoint] GO:0031573 [intra-S DNA damage checkpoint] GO:0035556 [intracellular signal transduction] GO:0044772 [mitotic cell cycle phase transition] GO:0046872 [metal ion binding] GO:1901990 [regulation of mitotic cell cycle phase transition] Show all	645 aa 74.2 kDa	No	0
NEK11-004 ENSP00000425114 ENST00000511262	Q8NG66 [Direct mapping] Serine/threonine-protein kinase Nek11 Show all	Enzymes ENZYME proteins Transferases Kinases NEK Ser/Thr protein kinases SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0006468 [protein phosphorylation] GO:0016572 [histone phosphorylation] GO:0031572 [G2 DNA damage checkpoint] GO:0031573 [intra-S DNA damage checkpoint] GO:0035556 [intracellular signal transduction] GO:0044772 [mitotic cell cycle phase transition] GO:0046872 [metal ion binding] GO:1901990 [regulation of mitotic cell cycle phase transition] Show all	470 aa 54 kDa	No	0
NEK11-005 ENSP00000421549 ENST00000510769	E9PHI8 [Direct mapping] Serine/threonine-protein kinase Nek11 Show all	Predicted intracellular proteins Show all	GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	540 aa 62.3 kDa	No	0
NEK11-006 ENSP00000423458 ENST00000510688	Q8NG66 [Direct mapping] Serine/threonine-protein kinase Nek11 Show all	Enzymes ENZYME proteins Transferases Kinases NEK Ser/Thr protein kinases THUMBUP predicted membrane proteins Predicted intracellular proteins Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0006468 [protein phosphorylation] GO:0016572 [histone phosphorylation] GO:0031572 [G2 DNA damage checkpoint] GO:0031573 [intra-S DNA damage checkpoint] GO:0035556 [intracellular signal transduction] GO:0044772 [mitotic cell cycle phase transition] GO:0046872 [metal ion binding] GO:1901990 [regulation of mitotic cell cycle phase transition] Show all	599 aa 68.9 kDa	No	0
NEK11-010 ENSP00000421851 ENST00000508196	Q8NG66 [Direct mapping] Serine/threonine-protein kinase Nek11 Show all	Enzymes ENZYME proteins Transferases Kinases NEK Ser/Thr protein kinases THUMBUP predicted membrane proteins Predicted intracellular proteins Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0006468 [protein phosphorylation] GO:0016572 [histone phosphorylation] GO:0031572 [G2 DNA damage checkpoint] GO:0031573 [intra-S DNA damage checkpoint] GO:0035556 [intracellular signal transduction] GO:0044772 [mitotic cell cycle phase transition] GO:0046872 [metal ion binding] GO:1901990 [regulation of mitotic cell cycle phase transition] Show all	645 aa 74.2 kDa	No	0
NEK11-201 ENSP00000349389 ENST00000356918	Q8NG66 [Direct mapping] Serine/threonine-protein kinase Nek11 Show all	Enzymes ENZYME proteins Transferases Kinases NEK Ser/Thr protein kinases SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0006468 [protein phosphorylation] GO:0016572 [histone phosphorylation] GO:0031572 [G2 DNA damage checkpoint] GO:0031573 [intra-S DNA damage checkpoint] GO:0035556 [intracellular signal transduction] GO:0044772 [mitotic cell cycle phase transition] GO:0046872 [metal ion binding] GO:1901990 [regulation of mitotic cell cycle phase transition] Show all	470 aa 54 kDa	No	0

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