Moderate nuclear positivity was observed in a few cases of lung cancers, malignant gliomas, lymphomas and melanomas. Remaining malignant cells were generally negative.
NEK11 (HGNC Symbol)
NIMA-related kinase 11 (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the never in mitosis gene A family of kinases. The encoded protein localizes to the nucleoli, and may function with NEK2A in the S-phase checkpoint. The encoded protein appears to play roles in DNA replication and response to genotoxic stress. Alternatively spliced transcript variants have been described.[provided by RefSeq, Mar 2009]