We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
Fields »
 

Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
ABOUT
HELP
BLOG
  • THE HUMAN PROTEOME
  • THE HUMAN TISSUES
  • THE HUMAN CELL
  • HUMAN PATHOLOGY
  • PROTEIN CLASSES
  • PROTEIN EVIDENCE
    • NEWS
    • BLOG
    • EVENTS
    • PRESS ROOM
    • LEARN
    • DICTIONARY
    • METHODS
    • CELL LINES
  • THE PROJECT
  • INTRODUCTION
  • ORGANIZATION
  • PUBLICATIONS
  • PUBLICATION DATA
  • ANTIBODY SUBMISSION
  • ANTIBODY AVAILABILITY
  • LINKS
  • CONTACT
  • TECHNICAL DATA
  • ANTIBODY VALIDATION
  • ASSAYS & ANNOTATION
  • DISCLAIMER
  • DOWNLOADABLE DATA
  • HELP & FAQ
  • LICENCE & CITATION
  • PRIVACY STATEMENT
  • RELEASE HISTORY
NEK11
  • TISSUE

  • premium

    CELL

  • PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

NEK11

Gene description

NIMA-related kinase 11

Protein class

Enzymes
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

7
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Tissue enhanced (fallopian tube)
GTEx:Mixed
FANTOM5:Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Nuclear expression in several tissues, most abundant in testis.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly not consistent with RNA expression data. External characterization data supports antibody staining.

Reliability score

Approved based on 1 antibody.
HPA016908
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
N/A
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Cerebellum

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (fallopian tube)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

NEK11 (HGNC Symbol)

Synonyms

FLJ23495

Description

NIMA-related kinase 11 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the never in mitosis gene A family of kinases. The encoded protein localizes to the nucleoli, and may function with NEK2A in the S-phase checkpoint. The encoded protein appears to play roles in DNA replication and response to genotoxic stress. Alternatively spliced transcript variants have been described.[provided by RefSeq, Mar 2009]

Chromosome

3

Cytoband

q22.1

Chromosome location (bp)

131026850 - 131350465

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000114670 (version 83.38)

Entrez gene

79858

UniProt

Q8NG66 (UniProt - Evidence at protein level)

neXtProt

NX_Q8NG66

Antibodypedia

NEK11 antibodies

PROTEIN BROWSER

NEK11-001
NEK11-003
NEK11-004
NEK11-005
NEK11-006
NEK11-010
NEK11-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

NEK11-001
ENSP00000426662
ENST00000507910
Q8NG66 [Direct mapping]
Serine/threonine-protein kinase Nek11
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   NEK Ser/Thr protein kinases
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0006468 [protein phosphorylation]
GO:0016572 [histone phosphorylation]
GO:0031572 [G2 DNA damage checkpoint]
GO:0031573 [intra-S DNA damage checkpoint]
GO:0035556 [intracellular signal transduction]
GO:0044772 [mitotic cell cycle phase transition]
GO:0046872 [metal ion binding]
GO:1901990 [regulation of mitotic cell cycle phase transition]
Show all
482 aa
55.5 kDa
No 0
NEK11-003
ENSP00000372857
ENST00000383366
Q8NG66 [Direct mapping]
Serine/threonine-protein kinase Nek11
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   NEK Ser/Thr protein kinases
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0006468 [protein phosphorylation]
GO:0016572 [histone phosphorylation]
GO:0031572 [G2 DNA damage checkpoint]
GO:0031573 [intra-S DNA damage checkpoint]
GO:0035556 [intracellular signal transduction]
GO:0044772 [mitotic cell cycle phase transition]
GO:0046872 [metal ion binding]
GO:1901990 [regulation of mitotic cell cycle phase transition]
Show all
645 aa
74.2 kDa
No 0
NEK11-004
ENSP00000425114
ENST00000511262
Q8NG66 [Direct mapping]
Serine/threonine-protein kinase Nek11
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   NEK Ser/Thr protein kinases
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0006468 [protein phosphorylation]
GO:0016572 [histone phosphorylation]
GO:0031572 [G2 DNA damage checkpoint]
GO:0031573 [intra-S DNA damage checkpoint]
GO:0035556 [intracellular signal transduction]
GO:0044772 [mitotic cell cycle phase transition]
GO:0046872 [metal ion binding]
GO:1901990 [regulation of mitotic cell cycle phase transition]
Show all
470 aa
54 kDa
No 0
NEK11-005
ENSP00000421549
ENST00000510769
E9PHI8 [Direct mapping]
Serine/threonine-protein kinase Nek11
Show all
Predicted intracellular proteins
Show all
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
540 aa
62.3 kDa
No 0
NEK11-006
ENSP00000423458
ENST00000510688
Q8NG66 [Direct mapping]
Serine/threonine-protein kinase Nek11
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   NEK Ser/Thr protein kinases
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0006468 [protein phosphorylation]
GO:0016572 [histone phosphorylation]
GO:0031572 [G2 DNA damage checkpoint]
GO:0031573 [intra-S DNA damage checkpoint]
GO:0035556 [intracellular signal transduction]
GO:0044772 [mitotic cell cycle phase transition]
GO:0046872 [metal ion binding]
GO:1901990 [regulation of mitotic cell cycle phase transition]
Show all
599 aa
68.9 kDa
No 0
NEK11-010
ENSP00000421851
ENST00000508196
Q8NG66 [Direct mapping]
Serine/threonine-protein kinase Nek11
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   NEK Ser/Thr protein kinases
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0006468 [protein phosphorylation]
GO:0016572 [histone phosphorylation]
GO:0031572 [G2 DNA damage checkpoint]
GO:0031573 [intra-S DNA damage checkpoint]
GO:0035556 [intracellular signal transduction]
GO:0044772 [mitotic cell cycle phase transition]
GO:0046872 [metal ion binding]
GO:1901990 [regulation of mitotic cell cycle phase transition]
Show all
645 aa
74.2 kDa
No 0
NEK11-201
ENSP00000349389
ENST00000356918
Q8NG66 [Direct mapping]
Serine/threonine-protein kinase Nek11
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   NEK Ser/Thr protein kinases
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0006468 [protein phosphorylation]
GO:0016572 [histone phosphorylation]
GO:0031572 [G2 DNA damage checkpoint]
GO:0031573 [intra-S DNA damage checkpoint]
GO:0035556 [intracellular signal transduction]
GO:0044772 [mitotic cell cycle phase transition]
GO:0046872 [metal ion binding]
GO:1901990 [regulation of mitotic cell cycle phase transition]
Show all
470 aa
54 kDa
No 0

Contact

  • BLOG
  • PRESS ROOM
  • contact@proteinatlas.org

The Project

  • INTRODUCTION
  • ORGANIZATION
  • PUBLICATIONS
  • DOWNLOADABLE DATA

The Human Protein Atlas

  • ANTIBODY AVAILABILITY
  • LICENCE & CITATION
  • HELP & FAQ
The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.