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NKTR

GENERAL INFORMATION

Gene name

 NKTR

Gene description

 Natural killer cell triggering receptor

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA022120
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PROGNOSTIC SUMMARY
Prognostic marker in urothelial cancer (favourable), head and neck cancer (favourable), renal cancer (unfavourable) and prostate cancer (unfavourable).
Urothelial cancer p<0.001
Head and neck cancer p<0.001
Renal cancer p<0.001
Prostate cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA022120

GENE INFORMATION

Gene name

 NKTR (HGNC Symbol)

Synonyms

 p104

Description

 Natural killer cell triggering receptor (HGNC Symbol)

Entrez gene summary

 This gene encodes a membrane-anchored protein with a hydrophobic amino terminal domain and a cyclophilin-like PPIase domain. It is present on the surface of natural killer cells and facilitates their binding to targets. Its expression is regulated by IL2 activation of the cells. [provided by RefSeq, Jul 2008]

Chromosome

 3

Cytoband

 p22.1

Chromosome location (bp)

 42600614 - 42648741

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000114857 (version 83.38)

Entrez gene

 4820

UniProt

 P30414 (UniProt - Evidence at protein level)

neXtProt

 NX_P30414

Antibodypedia

 NKTR antibodies

PROTEIN BROWSER
NKTR-001
NKTR-005
NKTR-010
NKTR-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NKTR-001
ENSP00000232978
ENST00000232978
P30414 [Direct mapping]
NK-tumor recognition protein Putative peptidyl-prolyl cis-trans isomerase
A0A024R2N6 [Target identity:100%; Query identity:100%]
Natural killer-tumor recognition sequence, isoform CRA_a
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Enzymes
   ENZYME proteins
   Isomerase
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000413 [protein peptidyl-prolyl isomerization]
GO:0003755 [peptidyl-prolyl cis-trans isomerase activity]
GO:0006457 [protein folding]
GO:0016018 [cyclosporin A binding]
GO:0016020 [membrane]
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 1462 aa
165.7 kDa 		No 0
NKTR-005
ENSP00000390259
ENST00000442970
A8K7K2 [Direct mapping]
Peptidyl-prolyl cis-trans isomerase
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000413 [protein peptidyl-prolyl isomerization]
GO:0003755 [peptidyl-prolyl cis-trans isomerase activity]
GO:0006457 [protein folding]
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 105 aa
11.8 kDa 		No 0
NKTR-010
ENSP00000408660
ENST00000445842
C9JMM5 [Direct mapping]
Peptidyl-prolyl cis-trans isomerase
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0000413 [protein peptidyl-prolyl isomerization]
GO:0003755 [peptidyl-prolyl cis-trans isomerase activity]
GO:0006457 [protein folding]
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 104 aa
11.6 kDa 		No 0
NKTR-201
ENSP00000482143
ENST00000617821
A0A087WYW3 [Direct mapping]
NK-tumor recognition protein
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000413 [protein peptidyl-prolyl isomerization]
GO:0003755 [peptidyl-prolyl cis-trans isomerase activity]
Show all
 1162 aa
131.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.