Expression of CLCN2 in cancer - Summary - The Human Protein Atlas

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CLCN2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CLCN2
Gene description	Chloride channel, voltage-sensitive 2
Protein class	Disease related genes FDA approved drug targets Plasma proteins Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Pending external verification.
Reliability score	Approved based on 3 antibodies. HPA014545 , HPA024108 , CAB009397
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA014545	HPA024108	CAB009397

GENE INFORMATION
Gene name	CLCN2 (HGNC Symbol)
Synonyms	ClC-2, CLC2, EJM6
Description	Chloride channel, voltage-sensitive 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a voltage-gated chloride channel. The encoded protein is a transmembrane protein that maintains chloride ion homeostasis in various cells. Defects in this gene may be a cause of certain epilepsies. Four transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2012]
Chromosome	3
Cytoband	q27.1
Chromosome location (bp)	184346185 - 184361651
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000114859 (version 83.38)
Entrez gene	1181
UniProt	P51788 (UniProt - Evidence at protein level)
neXtProt	NX_P51788
Antibodypedia	CLCN2 antibodies

PROTEIN BROWSER

CLCN2-001	CLCN2-002	CLCN2-003	CLCN2-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CLCN2-001 ENSP00000265593 ENST00000265593	P51788 [Direct mapping] Chloride channel protein 2 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Plasma proteins Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005216 [ion channel activity] GO:0005247 [voltage-gated chloride channel activity] GO:0005886 [plasma membrane] GO:0006810 [transport] GO:0006821 [chloride transport] GO:0016020 [membrane] GO:0034220 [ion transmembrane transport] GO:0034707 [chloride channel complex] GO:0055085 [transmembrane transport] GO:0060041 [retina development in camera-type eye] GO:0060689 [cell differentiation involved in salivary gland development] GO:1902476 [chloride transmembrane transport] GO:1903959 [regulation of anion transmembrane transport] Show all	898 aa 98.5 kDa	No	>9
CLCN2-002 ENSP00000391928 ENST00000457512	P51788 [Direct mapping] Chloride channel protein 2 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Plasma proteins Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005216 [ion channel activity] GO:0005247 [voltage-gated chloride channel activity] GO:0005886 [plasma membrane] GO:0006810 [transport] GO:0006821 [chloride transport] GO:0016020 [membrane] GO:0034220 [ion transmembrane transport] GO:0034707 [chloride channel complex] GO:0055085 [transmembrane transport] GO:1902476 [chloride transmembrane transport] GO:1903959 [regulation of anion transmembrane transport] Show all	869 aa 95.4 kDa	No	>9
CLCN2-003 ENSP00000400425 ENST00000434054	P51788 [Direct mapping] Chloride channel protein 2 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Plasma proteins Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005216 [ion channel activity] GO:0005247 [voltage-gated chloride channel activity] GO:0005886 [plasma membrane] GO:0006810 [transport] GO:0006821 [chloride transport] GO:0016020 [membrane] GO:0034220 [ion transmembrane transport] GO:0034707 [chloride channel complex] GO:0055085 [transmembrane transport] GO:1902476 [chloride transmembrane transport] GO:1903959 [regulation of anion transmembrane transport] Show all	854 aa 93.6 kDa	No	>9
CLCN2-004 ENSP00000345056 ENST00000344937	P51788 [Direct mapping] Chloride channel protein 2 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Plasma proteins Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005216 [ion channel activity] GO:0005247 [voltage-gated chloride channel activity] GO:0005886 [plasma membrane] GO:0006810 [transport] GO:0006821 [chloride transport] GO:0016020 [membrane] GO:0034220 [ion transmembrane transport] GO:0034707 [chloride channel complex] GO:0055085 [transmembrane transport] GO:1902476 [chloride transmembrane transport] GO:1903959 [regulation of anion transmembrane transport] Show all	881 aa 96.8 kDa	No	>9

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The Human Protein Atlas

The Human Protein Atlas project is funded
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