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EEF1B2

GENERAL INFORMATION

Gene name

 EEF1B2

Gene description

 Eukaryotic translation elongation factor 1 beta 2

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Supported based on 2 antibodies.
HPA035029 , CAB012477
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), breast cancer (favourable) and melanoma (unfavourable).
Renal cancer p<0.001
Breast cancer p<0.001
Melanoma p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA035029
CAB012477

GENE INFORMATION

Gene name

 EEF1B2

Synonyms

Description

 Eukaryotic translation elongation factor 1 beta 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a translation elongation factor. The protein is a guanine nucleotide exchange factor involved in the transfer of aminoacylated tRNAs to the ribosome. Alternative splicing results in three transcript variants which differ only in the 5' UTR. [provided by RefSeq, Jul 2008]

Chromosome

 2

Cytoband

 q33.3

Chromosome location (bp)

 206159585 - 206162928

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000114942 (version 83.38)

Entrez gene

 1933

UniProt

 P24534 (UniProt - Evidence at protein level)

neXtProt

 NX_P24534

Antibodypedia

 EEF1B2 antibodies

PROTEIN BROWSER
EEF1B2-001
EEF1B2-003
EEF1B2-004
EEF1B2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
EEF1B2-001
ENSP00000236957
ENST00000236957
P24534 [Direct mapping]
Elongation factor 1-beta
A0A024R3W7 [Target identity:100%; Query identity:100%]
Eukaryotic translation elongation factor 1 beta 2, isoform CRA_a
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003746 [translation elongation factor activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005829 [cytosol]
GO:0005853 [eukaryotic translation elongation factor 1 complex]
GO:0006412 [translation]
GO:0006414 [translational elongation]
GO:0010467 [gene expression]
GO:0044267 [cellular protein metabolic process]
Show all
 225 aa
24.8 kDa 		No 0
EEF1B2-003
ENSP00000376056
ENST00000392222
P24534 [Direct mapping]
Elongation factor 1-beta
A0A024R3W7 [Target identity:100%; Query identity:100%]
Eukaryotic translation elongation factor 1 beta 2, isoform CRA_a
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003746 [translation elongation factor activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005829 [cytosol]
GO:0005853 [eukaryotic translation elongation factor 1 complex]
GO:0006412 [translation]
GO:0006414 [translational elongation]
GO:0010467 [gene expression]
GO:0044267 [cellular protein metabolic process]
Show all
 225 aa
24.8 kDa 		No 0
EEF1B2-004
ENSP00000407730
ENST00000445505
C9JZW3 [Direct mapping]
Elongation factor 1-beta
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003746 [translation elongation factor activity]
GO:0005853 [eukaryotic translation elongation factor 1 complex]
GO:0006414 [translational elongation]
Show all
 123 aa
13.4 kDa 		No 0
EEF1B2-201
ENSP00000376055
ENST00000392221
P24534 [Direct mapping]
Elongation factor 1-beta
A0A024R3W7 [Target identity:100%; Query identity:100%]
Eukaryotic translation elongation factor 1 beta 2, isoform CRA_a
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003746 [translation elongation factor activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005829 [cytosol]
GO:0005853 [eukaryotic translation elongation factor 1 complex]
GO:0006412 [translation]
GO:0006414 [translational elongation]
GO:0010467 [gene expression]
GO:0044267 [cellular protein metabolic process]
Show all
 225 aa
24.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.